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An Integrative Framework for Combining Sequence and Epigenomic Data to Predict Transcription Factor Binding Sites Using Deep Learning 期刊论文
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2021, 卷号: 18, 期号: 1, 页码: 355-364
作者:  Jing, Fang;  Zhang, Shao-Wu;  Cao, Zhen;  Zhang, Shihua
收藏  |  浏览/下载：173/0  |  提交时间：2021/04/26
Bioinformatics  machine learning  transcription factors binding sites  convolutional neural networks  DNA accessibility  histone modification  
Prediction of enhancer-promoter interactions using the cross-cell type information and domain adversarial neural network 期刊论文
BMC BIOINFORMATICS, 2020, 卷号: 21, 期号: 1, 页码: 16
作者:  Jing, Fang;  Zhang, Shao-Wu;  Zhang, Shihua
收藏  |  浏览/下载：141/0  |  提交时间：2021/01/14
Enhancer–  promoter interactions  Cell line  Convolutional neural network  Transfer learning  Gradient reversal layer  
Probe Efficient Feature Representation of Gapped K-mer Frequency Vectors from Sequences Using Deep Neural Networks 期刊论文
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2020, 卷号: 17, 期号: 2, 页码: 657-667
作者:  Cao, Zhen;  Zhang, Shihua
收藏  |  浏览/下载：191/0  |  提交时间：2020/05/24
DNA  Bioinformatics  Kernel  Feature extraction  Support vector machines  Genomics  Task analysis  Bioinformatics  machine learning  gapped k-mer  deep neural network  transcription factor binding site prediction  
Simple tricks of convolutional neural network architectures improve DNA-protein binding prediction 期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 11, 页码: 1837-1843
作者:  Cao, Zhen;  Zhang, Shihua
收藏  |  浏览/下载：189/0  |  提交时间：2020/01/10
Matrix Integrative Analysis (MIA) of Multiple Genomic Data for Modular Patterns 期刊论文
FRONTIERS IN GENETICS, 2018, 卷号: 9, 页码: 12
作者:  Chen, Jinyu;  Zhang, Shihua
收藏  |  浏览/下载：176/0  |  提交时间：2018/07/30
bioinformatics  multi-dimensional genomics  matrix integrative analysis  data integration  module discovery  non-negative matrix factorization (NMF)  partial least squares (PLS)  
Comparative pan-cancer DNA methylation analysis reveals cancer common and specific patterns 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2017, 卷号: 18, 期号: 5, 页码: 761-773
作者:  Yang, Xiaofei;  Gao, Lin;  Zhang, Shihua
收藏  |  浏览/下载：139/0  |  提交时间：2018/07/30
cancer genomics  DNA-methylation  pan-cancer study  bioinformatics  
Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types 期刊论文
BRIEFINGS IN FUNCTIONAL GENOMICS, 2016, 卷号: 15, 期号: 6, 页码: 399-407
作者:  Yang, Xiaofei;  Shao, Xiaojian;  Gao, Lin;  Zhang, Shihua
收藏  |  浏览/下载：166/0  |  提交时间：2018/07/30
DNA methylation patterns  differentially methylation regions  comparative studies  tissue-specific methylation  cancer epigenomics  
An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 页码: 13
作者:  Cao, Zhen;  Zhang, Shihua
收藏  |  浏览/下载：132/0  |  提交时间：2018/07/30
Systematic DNA methylation analysis of multiple cell lines reveals common and specific patterns within and across tissues of origin 期刊论文
HUMAN MOLECULAR GENETICS, 2015, 卷号: 24, 期号: 15, 页码: 4374-4384
作者:  Yang, Xiaofei;  Shao, Xiaojian;  Gao, Lin;  Zhang, Shihua
收藏  |  浏览/下载：155/0  |  提交时间：2018/07/30