Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types

doi:10.1093/bfgp/elw013

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	Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types
	Yang, Xiaofei 2; Shao, Xiaojian 3; Gao, Lin 2; Zhang, Shihua1
	2016-11-01
发表期刊	BRIEFINGS IN FUNCTIONAL GENOMICS
ISSN	2041-2649
卷号	15 期号:6 页码:399-407
摘要	DNA methylation has been proved to play important roles in cell development and complex diseases through comparative studies of DNA methylation profiles across different tissues and samples. Current studies indicate that the regulation of DNA methylation to gene expression depends on the genomic locations of CpGs. Common DNA methylation patterns shared across different cell types and tissues are abundant, and they are likely involved in the basic functions of cell development, such as housekeeping functions. By way of contrast, cell type-specific DNA methylation patterns show distinct functional relevance with cell type specificity. Additionally, abnormal DNA methylation patterns are extensively involved in tumour development. Pan-cancer methylation patterns reveal common mechanisms and new similarities of different cancers, while cancer-specific patterns are relating to tumour heterogeneity and patient survival. Moreover, DNA methylation patterns in specific cancer are relevant with diverse regulatory elements such as enhancers and long non-coding RNAs. In this review, we survey the recent advances on DNA methylation patterns in normal or tumour states to illustrate their potential roles in cell development and cell canceration.
关键词	DNA methylation patterns differentially methylation regions comparative studies tissue-specific methylation cancer epigenomics
DOI	10.1093/bfgp/elw013
语种	英语
资助项目	National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61532014] ; National Natural Science Foundation of China[91530113] ; National Natural Science Foundation of China[61432010] ; National Natural Science Foundation of China[31201002] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; Key Laboratory of Random Complex Structures and Data Science at CAS ; Fundamental Research Funds for the Central Universities[BDZ021404]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000392717700002
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/24532
专题	应用数学研究所
通讯作者	Gao, Lin; Zhang, Shihua
作者单位	1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.Xidian Univ, Xian, Shaanxi, Peoples R China 3.Binzhou Univ, Binzhou, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiaofei,Shao, Xiaojian,Gao, Lin,et al. Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types[J]. BRIEFINGS IN FUNCTIONAL GENOMICS,2016,15(6):399-407.
APA	Yang, Xiaofei,Shao, Xiaojian,Gao, Lin,&Zhang, Shihua.(2016).Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types.BRIEFINGS IN FUNCTIONAL GENOMICS,15(6),399-407.
MLA	Yang, Xiaofei,et al."Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types".BRIEFINGS IN FUNCTIONAL GENOMICS 15.6(2016):399-407.