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Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types
Yang, Xiaofei2; Shao, Xiaojian3; Gao, Lin2; Zhang, Shihua1
2016-11-01
Source PublicationBRIEFINGS IN FUNCTIONAL GENOMICS
ISSN2041-2649
Volume15Issue:6Pages:399-407
AbstractDNA methylation has been proved to play important roles in cell development and complex diseases through comparative studies of DNA methylation profiles across different tissues and samples. Current studies indicate that the regulation of DNA methylation to gene expression depends on the genomic locations of CpGs. Common DNA methylation patterns shared across different cell types and tissues are abundant, and they are likely involved in the basic functions of cell development, such as housekeeping functions. By way of contrast, cell type-specific DNA methylation patterns show distinct functional relevance with cell type specificity. Additionally, abnormal DNA methylation patterns are extensively involved in tumour development. Pan-cancer methylation patterns reveal common mechanisms and new similarities of different cancers, while cancer-specific patterns are relating to tumour heterogeneity and patient survival. Moreover, DNA methylation patterns in specific cancer are relevant with diverse regulatory elements such as enhancers and long non-coding RNAs. In this review, we survey the recent advances on DNA methylation patterns in normal or tumour states to illustrate their potential roles in cell development and cell canceration.
KeywordDNA methylation patterns differentially methylation regions comparative studies tissue-specific methylation cancer epigenomics
DOI10.1093/bfgp/elw013
Language英语
Funding ProjectNational Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61532014] ; National Natural Science Foundation of China[91530113] ; National Natural Science Foundation of China[61432010] ; National Natural Science Foundation of China[31201002] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; Key Laboratory of Random Complex Structures and Data Science at CAS ; Fundamental Research Funds for the Central Universities[BDZ021404]
WOS Research AreaBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS SubjectBiotechnology & Applied Microbiology ; Genetics & Heredity
WOS IDWOS:000392717700002
PublisherOXFORD UNIV PRESS
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/24532
Collection应用数学研究所
Affiliation1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
2.Xidian Univ, Xian, Shaanxi, Peoples R China
3.Binzhou Univ, Binzhou, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xiaofei,Shao, Xiaojian,Gao, Lin,et al. Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types[J]. BRIEFINGS IN FUNCTIONAL GENOMICS,2016,15(6):399-407.
APA Yang, Xiaofei,Shao, Xiaojian,Gao, Lin,&Zhang, Shihua.(2016).Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types.BRIEFINGS IN FUNCTIONAL GENOMICS,15(6),399-407.
MLA Yang, Xiaofei,et al."Comparative DNA methylation analysis to decipher common and cell type-specific patterns among multiple cell types".BRIEFINGS IN FUNCTIONAL GENOMICS 15.6(2016):399-407.
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