An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures

doi:10.1038/srep33398

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	An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures
	Cao, Zhen; Zhang, Shihua
	2016-09-16
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6 页码:13
摘要	To investigate the commonalities and specificities across tumor lineages, we perform a systematic pan-cancer transcriptomic study across 6744 specimens. We find six pan-cancer subnetwork signatures which relate to cell cycle, immune response, Sp1 regulation, collagen, muscle system and angiogenesis. Moreover, four pan-cancer subnetwork signatures demonstrate strong prognostic potential. We also characterize 16 cancer type-specific subnetwork signatures which show diverse implications to somatic mutations, somatic copy number aberrations, DNA methylation alterations and clinical outcomes. Furthermore, some of them are strongly correlated with histological or molecular subtypes, indicating their implications with tumor heterogeneity. In summary, we systematically explore the pan-cancer common and cancer type-specific gene subnetwork signatures across multiple cancers, and reveal distinct commonalities and specificities among cancers at transcriptomic level.
DOI	10.1038/srep33398
语种	英语
资助项目	National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[11131009] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; CAS Frontier Science Research Key Project-Top Young Scientist[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science at CAS[2008DP173182]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000383644100001
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/23933
专题	应用数学研究所
通讯作者	Zhang, Shihua
作者单位	Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cao, Zhen,Zhang, Shihua. An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures[J]. SCIENTIFIC REPORTS,2016,6:13.
APA	Cao, Zhen,&Zhang, Shihua.(2016).An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures.SCIENTIFIC REPORTS,6,13.
MLA	Cao, Zhen,et al."An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures".SCIENTIFIC REPORTS 6(2016):13.