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An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures
Cao, Zhen; Zhang, Shihua
2016-09-16
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6Pages:13
AbstractTo investigate the commonalities and specificities across tumor lineages, we perform a systematic pan-cancer transcriptomic study across 6744 specimens. We find six pan-cancer subnetwork signatures which relate to cell cycle, immune response, Sp1 regulation, collagen, muscle system and angiogenesis. Moreover, four pan-cancer subnetwork signatures demonstrate strong prognostic potential. We also characterize 16 cancer type-specific subnetwork signatures which show diverse implications to somatic mutations, somatic copy number aberrations, DNA methylation alterations and clinical outcomes. Furthermore, some of them are strongly correlated with histological or molecular subtypes, indicating their implications with tumor heterogeneity. In summary, we systematically explore the pan-cancer common and cancer type-specific gene subnetwork signatures across multiple cancers, and reveal distinct commonalities and specificities among cancers at transcriptomic level.
DOI10.1038/srep33398
Language英语
Funding ProjectNational Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[11131009] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; CAS Frontier Science Research Key Project-Top Young Scientist[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science at CAS[2008DP173182]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000383644100001
PublisherNATURE PUBLISHING GROUP
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/23933
Collection应用数学研究所
AffiliationChinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Cao, Zhen,Zhang, Shihua. An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures[J]. SCIENTIFIC REPORTS,2016,6:13.
APA Cao, Zhen,&Zhang, Shihua.(2016).An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures.SCIENTIFIC REPORTS,6,13.
MLA Cao, Zhen,et al."An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures".SCIENTIFIC REPORTS 6(2016):13.
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