KMS Of Academy of mathematics and systems sciences, CAS
| An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures | |
Cao, Zhen; Zhang, Shihua
| |
| 2016-09-16 | |
| Source Publication | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| Volume | 6Pages:13 |
| Abstract | To investigate the commonalities and specificities across tumor lineages, we perform a systematic pan-cancer transcriptomic study across 6744 specimens. We find six pan-cancer subnetwork signatures which relate to cell cycle, immune response, Sp1 regulation, collagen, muscle system and angiogenesis. Moreover, four pan-cancer subnetwork signatures demonstrate strong prognostic potential. We also characterize 16 cancer type-specific subnetwork signatures which show diverse implications to somatic mutations, somatic copy number aberrations, DNA methylation alterations and clinical outcomes. Furthermore, some of them are strongly correlated with histological or molecular subtypes, indicating their implications with tumor heterogeneity. In summary, we systematically explore the pan-cancer common and cancer type-specific gene subnetwork signatures across multiple cancers, and reveal distinct commonalities and specificities among cancers at transcriptomic level. |
| DOI | 10.1038/srep33398 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[11131009] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; CAS Frontier Science Research Key Project-Top Young Scientist[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science at CAS[2008DP173182] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000383644100001 |
| Publisher | NATURE PUBLISHING GROUP |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/23933 |
| Collection | 应用数学研究所 |
| Corresponding Author | Zhang, Shihua |
| Affiliation | Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Cao, Zhen,Zhang, Shihua. An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures[J]. SCIENTIFIC REPORTS,2016,6:13. |
| APA | Cao, Zhen,&Zhang, Shihua.(2016).An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures.SCIENTIFIC REPORTS,6,13. |
| MLA | Cao, Zhen,et al."An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures".SCIENTIFIC REPORTS 6(2016):13. |
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