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BiTSC2: Bayesian inference of tumor clonal tree by joint analysis of single-cell SNV and CNA data 期刊论文
BRIEFINGS IN BIOINFORMATICS, 2022, 页码: 12
作者:  Chen, Ziwei;  Gong, Fuzhou;  Wan, Lin;  Ma, Liang
收藏  |  浏览/下载:172/0  |  提交时间:2022/06/21
single-cell DNA sequencing  intra-tumor heterogeneity  single nucleotide variation  copy number alteration  Bayesian modeling  cancer evolution  
Manifold alignment for heterogeneous single-cell multi-omics data integration using Pamona 期刊论文
BIOINFORMATICS, 2022, 卷号: 38, 期号: 1, 页码: 211-219
作者:  Cao, Kai;  Hong, Yiguang;  Wan, Lin
收藏  |  浏览/下载:146/0  |  提交时间:2022/04/02
NeuralEE: A GPU-Accelerated Elastic Embedding Dimensionality Reduction Method for Visualizing Large-Scale scRNA-Seq Data 期刊论文
FRONTIERS IN GENETICS, 2020, 卷号: 11, 页码: 8
作者:  Xiong, Jiankang;  Gong, Fuzhou;  Wan, Lin;  Ma, Liang
收藏  |  浏览/下载:176/0  |  提交时间:2021/01/14
single-cell RNA sequencing  elastic embedding  neural networks  large-scale  stochastic optimization  parametric models  generalizable models  
Unsupervised topological alignment for single-cell multi-omics integration 期刊论文
BIOINFORMATICS, 2020, 卷号: 36, 页码: 48-56
作者:  Cao, Kai;  Bai, Xiangqi;  Hong, Yiguang;  Wan, Lin
收藏  |  浏览/下载:121/0  |  提交时间:2021/01/14
RobustClone: a robust PCA method for tumor clone and evolution inference from single-cell sequencing data 期刊论文
BIOINFORMATICS, 2020, 卷号: 36, 期号: 11, 页码: 3299-3306
作者:  Chen, Ziwei;  Gong, Fuzhou;  Wan, Lin;  Ma, Liang
收藏  |  浏览/下载:171/0  |  提交时间:2020/09/23
A Branch Point on Differentiation Trajectory is the Bifurcating Event Revealed by Dynamical Network Biomarker Analysis of Single-Cell Data 期刊论文
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS, 2020, 卷号: 17, 期号: 2, 页码: 366-375
作者:  Chen, Ziwei;  Bai, Xiangqi;  Ma, Liang;  Wang, Xiawei;  Liu, Xiuqin;  Liu, Yuting;  Chen, Luonan;  Wan, Lin
收藏  |  浏览/下载:175/0  |  提交时间:2020/05/24
Trajectory  Heuristic algorithms  Mice  Correlation  Reactive power  Pseudo temporal trajectory  branch point  DNB theory  reconstruction  single-cell data  bifurcation  dynamical system  
Statistical test of structured continuous trees based on discordance matrix 期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 23, 页码: 4962-4970
作者:  Bai, Xiangqi;  Ma, Liang;  Wan, Lin
收藏  |  浏览/下载:134/0  |  提交时间:2020/05/24
DensityPath: an algorithm to visualize and reconstruct cell state-transition path on density landscape for single-cell RNA sequencing data 期刊论文
BIOINFORMATICS, 2019, 卷号: 35, 期号: 15, 页码: 2593-2601
作者:  Chen, Ziwei;  An, Shaokun;  Bai, Xiangqi;  Gong, Fuzhou;  Ma, Liang;  Wan, Lin
收藏  |  浏览/下载:193/0  |  提交时间:2020/01/10
TSEE: an elastic embedding method to visualize the dynamic gene expression patterns of time series single-cell RNA sequencing data 期刊论文
BMC GENOMICS, 2019, 卷号: 20, 页码: 16
作者:  An, Shaokun;  Ma, Liang;  Wan, Lin
收藏  |  浏览/下载:197/0  |  提交时间:2019/10/28
Nonlinear dimensionality reduction  Elastic embedding  Visualization  Single-cell RNA sequencing  Time series  Cell fate decisions  Gene expression pattern  Oscillation  In-group proportion