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iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity
Xu, Yan1; Ding, Ya-Xin1; Ding, Jun1; Lei, Ya-Hui1; Wu, Ling-Yun2; Deng, Nai-Yang3
2015-06-18
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume5Pages:6
AbstractLysine succinylation in protein is one type of post-translational modifications (PTMs). Succinylation is associated with some diseases and succinylated sites data just has been found in recent years in experiments. It is highly desired to develop computational methods to identify the candidate proteins and their sites. In view of this, a new predictor called iSuc-PseAAC was proposed by incorporating the peptide position-specific propensity into the general form of pseudo amino acid composition. The accuracy is 79.94%, sensitivity 51.07%, specificity 89.42% and MCC 0.431 in leave-one-out cross validation with support vector machine algorithm. It demonstrated by rigorous leaveone- out on stringent benchmark dataset that the new predictor is quite promising and may become a useful high throughput tool in this area. Meanwhile a user-friendly web-server for iSuc-PseAAC is accessible at http://app.aporc.org/iSuc-PseAAC/. Users can easily obtain their desired results without the need to understand the complicated mathematical equations presented in this paper just for its integrity.
DOI10.1038/srep10184
Language英语
Funding ProjectNatural Science Foundation of China[11301024] ; Natural Science Foundation of China[11371365] ; Natural Science Foundation of China[31201002] ; Natural Science Foundation of China[11131009]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000356523700001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/20056
Collection中国科学院数学与系统科学研究院
Affiliation1.Univ Sci & Technol Beijing, Dept Informat & Comp Sci, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China
3.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Xu, Yan,Ding, Ya-Xin,Ding, Jun,et al. iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity[J]. SCIENTIFIC REPORTS,2015,5:6.
APA Xu, Yan,Ding, Ya-Xin,Ding, Jun,Lei, Ya-Hui,Wu, Ling-Yun,&Deng, Nai-Yang.(2015).iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity.SCIENTIFIC REPORTS,5,6.
MLA Xu, Yan,et al."iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity".SCIENTIFIC REPORTS 5(2015):6.
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