iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity

doi:10.1038/srep10184

CSpace > 应用数学研究所

	iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity
	Xu, Yan 1; Ding, Ya-Xin 1; Ding, Jun 1; Lei, Ya-Hui 1; Wu, Ling-Yun2 ; Deng, Nai-Yang 3
	2015-06-18
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5 页码:6
摘要	Lysine succinylation in protein is one type of post-translational modifications (PTMs). Succinylation is associated with some diseases and succinylated sites data just has been found in recent years in experiments. It is highly desired to develop computational methods to identify the candidate proteins and their sites. In view of this, a new predictor called iSuc-PseAAC was proposed by incorporating the peptide position-specific propensity into the general form of pseudo amino acid composition. The accuracy is 79.94%, sensitivity 51.07%, specificity 89.42% and MCC 0.431 in leave-one-out cross validation with support vector machine algorithm. It demonstrated by rigorous leaveone- out on stringent benchmark dataset that the new predictor is quite promising and may become a useful high throughput tool in this area. Meanwhile a user-friendly web-server for iSuc-PseAAC is accessible at http://app.aporc.org/iSuc-PseAAC/. Users can easily obtain their desired results without the need to understand the complicated mathematical equations presented in this paper just for its integrity.
DOI	10.1038/srep10184
语种	英语
资助项目	Natural Science Foundation of China[11301024] ; Natural Science Foundation of China[11371365] ; Natural Science Foundation of China[31201002] ; Natural Science Foundation of China[11131009]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000356523700001
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/20056
专题	应用数学研究所
通讯作者	Xu, Yan
作者单位	1.Univ Sci & Technol Beijing, Dept Informat & Comp Sci, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Appl Math, Acad Math & Syst Sci, Beijing 100190, Peoples R China 3.China Agr Univ, Coll Sci, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yan,Ding, Ya-Xin,Ding, Jun,et al. iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity[J]. SCIENTIFIC REPORTS,2015,5:6.
APA	Xu, Yan,Ding, Ya-Xin,Ding, Jun,Lei, Ya-Hui,Wu, Ling-Yun,&Deng, Nai-Yang.(2015).iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity.SCIENTIFIC REPORTS,5,6.
MLA	Xu, Yan,et al."iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity".SCIENTIFIC REPORTS 5(2015):6.