A survey and systematic assessment of computational methods for drug response prediction

doi:10.1093/bib/bbz164

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	A survey and systematic assessment of computational methods for drug response prediction
	Chen, Jinyu 1,2; Zhang, Louxin 3,4
	2021
发表期刊	BRIEFINGS IN BIOINFORMATICS
ISSN	1467-5463
卷号	22 期号:1 页码:232-246
摘要	Drug response prediction arises from both basic and clinical research of personalized therapy, as well as drug discovery for cancers. With gene expression profiles and other omics data being available for over 1000 cancer cell lines and tissues, different machine learning approaches have been applied to drug response prediction. These methods appear in a body of literature and have been evaluated on different datasets with only one or two accuracy metrics. We systematically assess 17 representative methods for drug response prediction, which have been developed in the past 5 years, on four large public datasets in nine metrics. This study provides insights and lessons for future research into drug response prediction.
关键词	Drug response prediction regression model low rank matrix factorization based approach Bayesian inference deep learning benchmark
DOI	10.1093/bib/bbz164
收录类别	SCI
语种	英语
资助项目	Singapore National Research Fund[NRF2016NRF-NSFC001-026]
WOS研究方向	Biochemistry & Molecular Biology ; Mathematical & Computational Biology
WOS类目	Biochemical Research Methods ; Mathematical & Computational Biology
WOS记录号	WOS:000634950200019
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/58452
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Louxin
作者单位	1.Natl Univ Singapore, Dept Math, Singapore, Singapore 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Natl Univ Singapore, Dept Math & Computat Biol Programme, Singapore 119076, Singapore 4.Univ Waterloo, Comp Sci, Waterloo, ON N2L 3G1, Canada
推荐引用方式 GB/T 7714	Chen, Jinyu,Zhang, Louxin. A survey and systematic assessment of computational methods for drug response prediction[J]. BRIEFINGS IN BIOINFORMATICS,2021,22(1):232-246.
APA	Chen, Jinyu,&Zhang, Louxin.(2021).A survey and systematic assessment of computational methods for drug response prediction.BRIEFINGS IN BIOINFORMATICS,22(1),232-246.
MLA	Chen, Jinyu,et al."A survey and systematic assessment of computational methods for drug response prediction".BRIEFINGS IN BIOINFORMATICS 22.1(2021):232-246.