Integrative cancer genomics: models, algorithms and analysis

doi:10.1007/s11704-016-5568-5

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	Integrative cancer genomics: models, algorithms and analysis
	Chen, Jinyu; Zhang, Shihua
	2017-06-01
发表期刊	FRONTIERS OF COMPUTER SCIENCE
ISSN	2095-2228
卷号	11 期号:3 页码:392-406
摘要	In the past decade, the remarkable development of high-throughput sequencing technology accelerates the generation of large amount of multiple dimensional data such as genomic, epigenomic, transcriptomic and proteomic data. The comprehensive data make it possible to understand the underlying mechanisms of biology and disease such as cancer systematically. It also provides great challenges for computational cancer genomics due to the complexity, scale and noise of data. In this article, we aim to review the recent developments and progresses of computational models, algorithms and analysis of complex data in cancer genomics. These topics of this paper include the identification of driver mutations, the genetic heterogeneity analysis, genomic markers discovery of drug response, pan-cancer scale analysis and so on.
关键词	cancer genomics model algorithm data integration bioinformatics computational biology
DOI	10.1007/s11704-016-5568-5
语种	英语
资助项目	National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11131009] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science, CAS[2008DP173182]
WOS研究方向	Computer Science
WOS类目	Computer Science, Information Systems ; Computer Science, Software Engineering ; Computer Science, Theory & Methods
WOS记录号	WOS:000402062400003
出版者	HIGHER EDUCATION PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/25506
专题	应用数学研究所
通讯作者	Zhang, Shihua
作者单位	Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chen, Jinyu,Zhang, Shihua. Integrative cancer genomics: models, algorithms and analysis[J]. FRONTIERS OF COMPUTER SCIENCE,2017,11(3):392-406.
APA	Chen, Jinyu,&Zhang, Shihua.(2017).Integrative cancer genomics: models, algorithms and analysis.FRONTIERS OF COMPUTER SCIENCE,11(3),392-406.
MLA	Chen, Jinyu,et al."Integrative cancer genomics: models, algorithms and analysis".FRONTIERS OF COMPUTER SCIENCE 11.3(2017):392-406.