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Integrative cancer genomics: models, algorithms and analysis
Chen, Jinyu; Zhang, Shihua
AbstractIn the past decade, the remarkable development of high-throughput sequencing technology accelerates the generation of large amount of multiple dimensional data such as genomic, epigenomic, transcriptomic and proteomic data. The comprehensive data make it possible to understand the underlying mechanisms of biology and disease such as cancer systematically. It also provides great challenges for computational cancer genomics due to the complexity, scale and noise of data. In this article, we aim to review the recent developments and progresses of computational models, algorithms and analysis of complex data in cancer genomics. These topics of this paper include the identification of driver mutations, the genetic heterogeneity analysis, genomic markers discovery of drug response, pan-cancer scale analysis and so on.
Keywordcancer genomics model algorithm data integration bioinformatics computational biology
Funding ProjectNational Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11131009] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science, CAS[2008DP173182]
WOS Research AreaComputer Science
WOS SubjectComputer Science, Information Systems ; Computer Science, Software Engineering ; Computer Science, Theory & Methods
WOS IDWOS:000402062400003
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Document Type期刊论文
Corresponding AuthorZhang, Shihua
AffiliationChinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jinyu,Zhang, Shihua. Integrative cancer genomics: models, algorithms and analysis[J]. FRONTIERS OF COMPUTER SCIENCE,2017,11(3):392-406.
APA Chen, Jinyu,&Zhang, Shihua.(2017).Integrative cancer genomics: models, algorithms and analysis.FRONTIERS OF COMPUTER SCIENCE,11(3),392-406.
MLA Chen, Jinyu,et al."Integrative cancer genomics: models, algorithms and analysis".FRONTIERS OF COMPUTER SCIENCE 11.3(2017):392-406.
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