Reconstruction of DNA sequencing by hybridization

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	Reconstruction of DNA sequencing by hybridization
	Zhang, JH; Wu, LY; Zhang, XS
	2003
发表期刊	BIOINFORMATICS
ISSN	1367-4803
卷号	19 期号:1 页码:14-21
摘要	Motivation: It is widely recognized that the hybridization process is prone to errors and that the future of DNA sequencing by hybridization is predicated on the ability to successfully cope with such errors. However, the occurrence of hybridization errors results in the computational difficulty of the reconstruction of DNA sequencing by hybridization. The reconstruction problem of DNA sequencing by hybridization with errors is a strongly NP-hard problem. So far the problem has not been solved well. Results: In this paper, a new approach is presented to solve the reconstruction problem of DNA sequencing by hybridization, which realizes the computational part of the SBH experiment. The proposed algorithm accepts both the negative and positive errors. The computational experiments show that the algorithm behaves satisfactorily, especially for the case with k-tuple repetitions and positive errors.
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS类目	Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability
WOS记录号	WOS:000180463900004
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/18819
专题	应用数学研究所
通讯作者	Zhang, JH
作者单位	Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhang, JH,Wu, LY,Zhang, XS. Reconstruction of DNA sequencing by hybridization[J]. BIOINFORMATICS,2003,19(1):14-21.
APA	Zhang, JH,Wu, LY,&Zhang, XS.(2003).Reconstruction of DNA sequencing by hybridization.BIOINFORMATICS,19(1),14-21.
MLA	Zhang, JH,et al."Reconstruction of DNA sequencing by hybridization".BIOINFORMATICS 19.1(2003):14-21.