Protein evolution in yeast transcription factor subnetworks

doi:10.1093/nar/gkq353

CSpace > 应用数学研究所

	Protein evolution in yeast transcription factor subnetworks
	Wang, Yong1,2 ; Franzosa, Eric A.1; Zhang, Xiang-Sun2 ; Xia, Yu 1,3,4
	2010-10-01
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	38 期号:18 页码:5959-5969
摘要	When averaged over the full yeast protein-protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-wide analysis of protein evolution in the subnetworks of associations involving yeast transcription factors (TFs) reveals that TF hubs do not tend to evolve significantly more slowly than TF non-hubs. This result holds for all four major types of TF hubs: interaction hubs, regulatory in-degree and out-degree hubs, as well as co-regulatory hubs that jointly regulate target genes with many TFs. Furthermore, TF regulatory in-degree hubs tend to evolve significantly more quickly than TF non-hubs. Most importantly, the correlations between evolutionary rate (K(A)/K(S)) and degrees for TFs are significantly more positive than those for generic proteins within the same global protein-protein interaction and transcriptional regulatory networks. Compared to generic protein hubs, TF hubs operate at a higher level in the hierarchical structure of cellular networks, and hence experience additional evolutionary forces (relaxed negative selection or positive selection through network rewiring). The striking difference between the evolution of TF hubs and generic protein hubs demonstrates that components within the same global network can be governed by distinct organizational and evolutionary principles.
DOI	10.1093/nar/gkq353
语种	英语
资助项目	National Natural Science Foundation of China[10801131] ; National Natural Science Foundation of China[10631070] ; National Science Foundation (IGERT)[DGE-0654108] ; Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation ; K.C. Wong Education Foundation, Hong Kong
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000283116600008
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/9401
专题	应用数学研究所
通讯作者	Xia, Yu
作者单位	1.Boston Univ, Bioinformat Program, Boston, MA 02215 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 3.Boston Univ, Dept Chem, Boston, MA 02215 USA 4.Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
推荐引用方式 GB/T 7714	Wang, Yong,Franzosa, Eric A.,Zhang, Xiang-Sun,et al. Protein evolution in yeast transcription factor subnetworks[J]. NUCLEIC ACIDS RESEARCH,2010,38(18):5959-5969.
APA	Wang, Yong,Franzosa, Eric A.,Zhang, Xiang-Sun,&Xia, Yu.(2010).Protein evolution in yeast transcription factor subnetworks.NUCLEIC ACIDS RESEARCH,38(18),5959-5969.
MLA	Wang, Yong,et al."Protein evolution in yeast transcription factor subnetworks".NUCLEIC ACIDS RESEARCH 38.18(2010):5959-5969.