Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies

doi:10.1111/j.1469-1809.2009.00506.x

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	Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies
	Li, Qizhai1,2 ; Zheng, Gang 3; Liang, Xueying 1; Yu, Kai 1
	2009-03-01
发表期刊	ANNALS OF HUMAN GENETICS
ISSN	0003-4800
卷号	73 页码:245-252
摘要	Choosing an appropriate single-marker association test is critical to the success of case-control genetic association studies. An ideal single-marker analysis should have robust performance across a wide range of potential disease risk models. MAX was designed specifically to achieve such robustness. In this work, we derived the power calculation formula for MAX and conducted a comprehensive power comparison between MAX and two other commonly used single-marker tests, the one-degree-of-freedom (1-df) Cochran-Armitage trend test and the 2-df Pearson chi(2) test. We used a single-marker disease risk model and a two-marker haplotype risk model to explore the performances of the above three tests. We found that each test has its own "sweet" spots. Among the three tests considered, MAX appears to have the most robust performance.
关键词	Association chi(2) genetic model MAX power robustness
DOI	10.1111/j.1469-1809.2009.00506.x
语种	英语
资助项目	Intramural Program of the National Institutes of Health ; Knowledge Innovation Program of the Chinese Academy of Sciences[30465W0] ; Knowledge Innovation Program of the Chinese Academy of Sciences[30475V0]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000263448700013
出版者	WILEY-BLACKWELL PUBLISHING, INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/8984
专题	系统科学研究所
通讯作者	Yu, Kai
作者单位	1.Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 3.NHLBI, Off Biostat Res, Off Director, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Li, Qizhai,Zheng, Gang,Liang, Xueying,et al. Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies[J]. ANNALS OF HUMAN GENETICS,2009,73:245-252.
APA	Li, Qizhai,Zheng, Gang,Liang, Xueying,&Yu, Kai.(2009).Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies.ANNALS OF HUMAN GENETICS,73,245-252.
MLA	Li, Qizhai,et al."Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies".ANNALS OF HUMAN GENETICS 73(2009):245-252.