A weighted rank-sum procedure for comparing samples with multiple endpoints

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	A weighted rank-sum procedure for comparing samples with multiple endpoints
	Li, Qizhai1,2 ; Liu, Aiyi ; Yu, Kai 1; Yu, Kai F.
	2009
发表期刊	STATISTICS AND ITS INTERFACE
ISSN	1938-7989
卷号	2 期号:2 页码:197-201
摘要	For comparing the distribution of two samples with multiple endpoints, O'Brien (1984) proposed rank-sum-type test statistics. Huang et al. (2005) extended these statistics to the general nonparametric Behrens-Fisher hypothesis problem and obtained improved test statistics by replacing the ad hoc variance with the asymptotic variance of the rank-sum statistics. In this paper we generalize the work of O'Brien (1984) and Huang et al. (2005) and propose a weighted rank-sum statistic. We show that the weighted rank-sum statistic is asymptotically normally distributed, permitting the computation of power, p-values and confidence intervals. We further demonstrate via simulation that the weighted rank-sum statistic is efficient in controlling the type I error rate and under certain alternatives, is more powerful than the statistics of O'Brien (1984) and Huang et al. (2005).
关键词	Asymptotic normality Behrens-Fisher problem Case-Control Clinical trials Multiple endpoints Rank-sum statistics Weights
语种	英语
资助项目	National Institutes of Health ; Chinese Academy of Sciences
WOS研究方向	Mathematical & Computational Biology ; Mathematics
WOS类目	Mathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS记录号	WOS:000282649700010
出版者	INT PRESS BOSTON, INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/8668
专题	系统科学研究所
作者单位	1.NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Li, Qizhai,Liu, Aiyi,Yu, Kai,et al. A weighted rank-sum procedure for comparing samples with multiple endpoints[J]. STATISTICS AND ITS INTERFACE,2009,2(2):197-201.
APA	Li, Qizhai,Liu, Aiyi,Yu, Kai,&Yu, Kai F..(2009).A weighted rank-sum procedure for comparing samples with multiple endpoints.STATISTICS AND ITS INTERFACE,2(2),197-201.
MLA	Li, Qizhai,et al."A weighted rank-sum procedure for comparing samples with multiple endpoints".STATISTICS AND ITS INTERFACE 2.2(2009):197-201.