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Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty
Hu, Xiaonan1; Meng, Zhen2
2022-05-18
Source PublicationANNALS OF HUMAN GENETICS
ISSN0003-4800
Pages11
AbstractOne of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. However, the underlying genetic models of inheritance are rarely known in practice. Misspecifying a genetic model may result in power loss. By using some potential genetic variables to separate the genotype coding and genetic model parameter, we construct a model-embedded score test (MEST). Our test is free of assumption of gene-environment independence and allows for covariates in the model. An effective sequential optimization algorithm is developed. Extensive simulations show the proposed MEST is robust and powerful in most of scenarios. Finally, we apply the proposed method to rheumatoid arthritis data from the Genetic Analysis Workshop 16 to further investigate the potential interaction effects.
Keywordgene-environment interaction gene-gene interaction genetic model potential variable power
DOI10.1111/ahg.12470
Indexed BySCI
Language英语
Funding ProjectCapital University of Economics and Business Newly Recruited Young Teachers Scientific Research Start-up Foundation Project[XRZ2022066]
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000796863600001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/61319
Collection中国科学院数学与系统科学研究院
Corresponding AuthorMeng, Zhen
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, Beijing, Peoples R China
2.Capital Univ Econ & Business, Sch Stat, Xincun St, Beijing 100070, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xiaonan,Meng, Zhen. Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty[J]. ANNALS OF HUMAN GENETICS,2022:11.
APA Hu, Xiaonan,&Meng, Zhen.(2022).Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty.ANNALS OF HUMAN GENETICS,11.
MLA Hu, Xiaonan,et al."Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty".ANNALS OF HUMAN GENETICS (2022):11.
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