KMS Of Academy of mathematics and systems sciences, CAS
| Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty | |
| Hu, Xiaonan1; Meng, Zhen2 | |
| 2022-05-18 | |
| Source Publication | ANNALS OF HUMAN GENETICS
 |
| ISSN | 0003-4800 |
| Pages | 11 |
| Abstract | One of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. However, the underlying genetic models of inheritance are rarely known in practice. Misspecifying a genetic model may result in power loss. By using some potential genetic variables to separate the genotype coding and genetic model parameter, we construct a model-embedded score test (MEST). Our test is free of assumption of gene-environment independence and allows for covariates in the model. An effective sequential optimization algorithm is developed. Extensive simulations show the proposed MEST is robust and powerful in most of scenarios. Finally, we apply the proposed method to rheumatoid arthritis data from the Genetic Analysis Workshop 16 to further investigate the potential interaction effects. |
| Keyword | gene-environment interaction gene-gene interaction genetic model potential variable power |
| DOI | 10.1111/ahg.12470 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Capital University of Economics and Business Newly Recruited Young Teachers Scientific Research Start-up Foundation Project[XRZ2022066] |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000796863600001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/61319 |
| Collection | 中国科学院数学与系统科学研究院 |
| Corresponding Author | Meng, Zhen |
| Affiliation | 1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, Beijing, Peoples R China 2.Capital Univ Econ & Business, Sch Stat, Xincun St, Beijing 100070, Peoples R China |
| Recommended Citation GB/T 7714 | Hu, Xiaonan,Meng, Zhen. Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty[J]. ANNALS OF HUMAN GENETICS,2022:11. |
| APA | Hu, Xiaonan,&Meng, Zhen.(2022).Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty.ANNALS OF HUMAN GENETICS,11. |
| MLA | Hu, Xiaonan,et al."Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty".ANNALS OF HUMAN GENETICS (2022):11. |
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