Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty

doi:10.1111/ahg.12470

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	Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty
	Hu, Xiaonan 1; Meng, Zhen 2
	2022-05-18
发表期刊	ANNALS OF HUMAN GENETICS
ISSN	0003-4800
页码	11
摘要	One of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. However, the underlying genetic models of inheritance are rarely known in practice. Misspecifying a genetic model may result in power loss. By using some potential genetic variables to separate the genotype coding and genetic model parameter, we construct a model-embedded score test (MEST). Our test is free of assumption of gene-environment independence and allows for covariates in the model. An effective sequential optimization algorithm is developed. Extensive simulations show the proposed MEST is robust and powerful in most of scenarios. Finally, we apply the proposed method to rheumatoid arthritis data from the Genetic Analysis Workshop 16 to further investigate the potential interaction effects.
关键词	gene-environment interaction gene-gene interaction genetic model potential variable power
DOI	10.1111/ahg.12470
收录类别	SCI
语种	英语
资助项目	Capital University of Economics and Business Newly Recruited Young Teachers Scientific Research Start-up Foundation Project[XRZ2022066]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000796863600001
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/61319
专题	中国科学院数学与系统科学研究院
通讯作者	Meng, Zhen
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, Beijing, Peoples R China 2.Capital Univ Econ & Business, Sch Stat, Xincun St, Beijing 100070, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xiaonan,Meng, Zhen. Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty[J]. ANNALS OF HUMAN GENETICS,2022:11.
APA	Hu, Xiaonan,&Meng, Zhen.(2022).Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty.ANNALS OF HUMAN GENETICS,11.
MLA	Hu, Xiaonan,et al."Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty".ANNALS OF HUMAN GENETICS (2022):11.