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A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study
Li, Zhengbang1; Qin, Sanan1; Li, Qizhai2,3
2021-05-10
Source PublicationSTATISTICS IN MEDICINE
ISSN0277-6715
Volume40Issue:10Pages:2422-2434
AbstractIn this article, we propose a novel test via combining the maximum and minimum values among a large number of dependent Z-scores for testing the hypothesis with sparse signals. The proposed test employs the information about different signs of maximum and minimum Z-scores and thus power is gained. Its asymptotic null distribution is derived under the null hypothesis and some regular conditions. Extensive simulation studies are conducted to show the advantages of the proposed test by comparing with two existing ones. A real application to the lipids genome wide association study further shows its performances.
Keywordasymptotic distribution maximum minimum power Z‐ score
DOI10.1002/sim.8912
Indexed BySCI
Language英语
Funding ProjectBeijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; Self-determined research funds of CCNU from the colleges' basic research of MOE[CCNU20TS002]
WOS Research AreaMathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
WOS SubjectMathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability
WOS IDWOS:000625327800001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/58315
Collection中国科学院数学与系统科学研究院
Corresponding AuthorLi, Qizhai
Affiliation1.Cent China Normal Univ, Sch Math & Stat, Wuhan, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, LSC, Zhongguancun East Rd,55, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhengbang,Qin, Sanan,Li, Qizhai. A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study[J]. STATISTICS IN MEDICINE,2021,40(10):2422-2434.
APA Li, Zhengbang,Qin, Sanan,&Li, Qizhai.(2021).A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study.STATISTICS IN MEDICINE,40(10),2422-2434.
MLA Li, Zhengbang,et al."A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study".STATISTICS IN MEDICINE 40.10(2021):2422-2434.
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