A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study

doi:10.1002/sim.8912

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	A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study
	Li, Zhengbang 1; Qin, Sanan 1; Li, Qizhai 2,3
	2021-05-10
发表期刊	STATISTICS IN MEDICINE
ISSN	0277-6715
卷号	40 期号:10 页码:2422-2434
摘要	In this article, we propose a novel test via combining the maximum and minimum values among a large number of dependent Z-scores for testing the hypothesis with sparse signals. The proposed test employs the information about different signs of maximum and minimum Z-scores and thus power is gained. Its asymptotic null distribution is derived under the null hypothesis and some regular conditions. Extensive simulation studies are conducted to show the advantages of the proposed test by comparing with two existing ones. A real application to the lipids genome wide association study further shows its performances.
关键词	asymptotic distribution maximum minimum power Z‐ score
DOI	10.1002/sim.8912
收录类别	SCI
语种	英语
资助项目	Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; Self-determined research funds of CCNU from the colleges' basic research of MOE[CCNU20TS002]
WOS研究方向	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
WOS类目	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability
WOS记录号	WOS:000625327800001
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/58315
专题	中国科学院数学与系统科学研究院
通讯作者	Li, Qizhai
作者单位	1.Cent China Normal Univ, Sch Math & Stat, Wuhan, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, LSC, Zhongguancun East Rd,55, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhengbang,Qin, Sanan,Li, Qizhai. A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study[J]. STATISTICS IN MEDICINE,2021,40(10):2422-2434.
APA	Li, Zhengbang,Qin, Sanan,&Li, Qizhai.(2021).A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study.STATISTICS IN MEDICINE,40(10),2422-2434.
MLA	Li, Zhengbang,et al."A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study".STATISTICS IN MEDICINE 40.10(2021):2422-2434.