Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies

doi:10.1186/s12874-021-01239-4

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	Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies
	Zhang, Wei 1; Zhang, Zhiwei 2; Krushkal, Julia 2; Liu, Aiyi 3
	2021-03-19
发表期刊	BMC MEDICAL RESEARCH METHODOLOGY
卷号	21 期号:1 页码:10
摘要	Background Cancer treatment is increasingly dependent on biomarkers for prognostication and treatment selection. Potential biomarkers are frequently evaluated in prospective-retrospective studies in which biomarkers are measured retrospectively on archived specimens after completion of prospective clinical trials. In light of the high costs of some assays, random sampling designs have been proposed that measure biomarkers for a random sub-sample of subjects selected on the basis of observed outcome and possibly other variables. Compared with a standard design that measures biomarkers on all subjects, a random sampling design can be cost-efficient in the sense of reducing the cost of the study substantially while achieving a reasonable level of precision. Methods For a biomarker that indicates the presence of some molecular alteration (e.g., mutation in a gene), we explore the use of a group testing strategy, which involves physically pooling specimens across subjects and assaying pooled samples for the presence of the molecular alteration of interest, for further improvement in cost-efficiency beyond random sampling. We propose simple and general approaches to estimating the prognostic and predictive values of biomarkers with group testing, and conduct simulation studies to validate the proposed estimation procedures and to assess the cost-efficiency of the group testing design in comparison to the standard and random sampling designs. Results Simulation results show that the proposed estimation procedures perform well in realistic settings and that a group testing design can have considerably higher cost-efficiency than a random sampling design. Conclusions Group testing can be used to improve the cost-efficiency of biomarker studies.
关键词	Biomarker study design Cost-efficiency Group testing Pooling Two-phase sampling
DOI	10.1186/s12874-021-01239-4
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[12001522] ; National Institutes of Health (NIH)
WOS研究方向	Health Care Sciences & Services
WOS类目	Health Care Sciences & Services
WOS记录号	WOS:000630733800001
出版者	BMC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/58261
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Zhiwei
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, LSC, Beijing, Peoples R China 2.NCI, Biometr Res Program, Div Canc Treatment & Diagnost, NIH, Bethesda, MD 20892 USA 3.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA
推荐引用方式 GB/T 7714	Zhang, Wei,Zhang, Zhiwei,Krushkal, Julia,et al. Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies[J]. BMC MEDICAL RESEARCH METHODOLOGY,2021,21(1):10.
APA	Zhang, Wei,Zhang, Zhiwei,Krushkal, Julia,&Liu, Aiyi.(2021).Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies.BMC MEDICAL RESEARCH METHODOLOGY,21(1),10.
MLA	Zhang, Wei,et al."Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies".BMC MEDICAL RESEARCH METHODOLOGY 21.1(2021):10.