Improved correction for population stratification in genome-wide association studies by identifying hidden population structures

doi:10.1002/gepi.20296

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	Improved correction for population stratification in genome-wide association studies by identifying hidden population structures
	Li, Qizhai1,2 ; Yu, Kai 1
	2008-04-01
发表期刊	GENETIC EPIDEMIOLOGY
ISSN	0741-0395
卷号	32 期号:3 页码:215-226
摘要	Hidden population substructure can cause population stratification and lead to false-positive findings in population-based genome-wide association (GWA) studies. Given a large panel of markers scanned in a GWA study, it becomes increasingly feasible to uncover the hidden population substructure within the study sample based on measured genotypes across the genome. Recognizing that population substructure can be displayed as clustered and/or continuous patterns of genetic variation, we propose a method that aims at the detection and correction of the confounding effect resulting from both patterns of population substructure. The proposed method is an extension of the EIGENSTRAT method (Price et al. [2006] Nat Genet 38:904-909). This approach is computationally feasible and easily applied to large-scale GWA studies. We show through simulation studies that, compared with the EIGENSTRAT method, the new method requires a smaller number of markers and yields a more appropriate correction for population stratification.
关键词	population stratification genome-wide association studies likelihood ratio test multidimensional scaling
DOI	10.1002/gepi.20296
语种	英语
WOS研究方向	Genetics & Heredity ; Public, Environmental & Occupational Health
WOS类目	Genetics & Heredity ; Public, Environmental & Occupational Health
WOS记录号	WOS:000254690500003
出版者	WILEY-BLACKWELL
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/5488
专题	系统科学研究所
通讯作者	Yu, Kai
作者单位	1.NCI, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Li, Qizhai,Yu, Kai. Improved correction for population stratification in genome-wide association studies by identifying hidden population structures[J]. GENETIC EPIDEMIOLOGY,2008,32(3):215-226.
APA	Li, Qizhai,&Yu, Kai.(2008).Improved correction for population stratification in genome-wide association studies by identifying hidden population structures.GENETIC EPIDEMIOLOGY,32(3),215-226.
MLA	Li, Qizhai,et al."Improved correction for population stratification in genome-wide association studies by identifying hidden population structures".GENETIC EPIDEMIOLOGY 32.3(2008):215-226.