KMS Of Academy of mathematics and systems sciences, CAS
| AssocTests: An R Package for Genetic Association Studies | |
| Wang, Lin1; Zhang, Wei2; Li, Qizhai2,3 | |
| 2020-06-01 | |
| Source Publication | JOURNAL OF STATISTICAL SOFTWARE
 |
| ISSN | 1548-7660 |
| Volume | 94Issue:5Pages:1-26 |
| Abstract | The R package AssocTests provides some procedures which are commonly used in genetic association studies. These procedures are population stratification correction through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance regression, single-marker test, maximum test based on three Cochran-Armitage trend tests, non-parametric trend test, and non-parametric maximum test. The trait values for these methods should be discrete or continuous. The discrete traits can be coded by 1/0 for cases/controls. The genotype values can be 0, 1, or 2 indicating the number of risk alleles for a biallelic single-nucleotide polymorphism. This article introduces the methods and algorithms implemented in the package. Some examples are provided to illustrate the package's capability. |
| Keyword | distance regression genetic association studies population stratification Tracy-Widom test R |
| DOI | 10.18637/iss.v04.i05 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Special National Key Research and Development Plan[2016YFD0400206] ; Beijing Natural Science Foundation[Z180006] ; National Science Foundation of China[11722113] ; National Nature Science Foundation of China[11701391] ; Scientific Research Level Improvement Quota Project of Capital University of Economics and Business ; 100 Talents Program of The Chinese Academy of Sciences for Young Scholars ; National Institutes of Health[NO1-AR-2-2263] ; National Institutes of Health[RO1-AR-44422] ; National Arthritis Foundation |
| WOS Research Area | Computer Science ; Mathematics |
| WOS Subject | Computer Science, Interdisciplinary Applications ; Statistics & Probability |
| WOS ID | WOS:000552355700001 |
| Publisher | JOURNAL STATISTICAL SOFTWARE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/51859 |
| Collection | 中国科学院数学与系统科学研究院 |
| Corresponding Author | Li, Qizhai |
| Affiliation | 1.Capital Univ Econ & Business, Sch Stat, 121 Zhangjialukou, Beijing 100070, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, LSC, 55 Zhongguancun East Rd, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Lin,Zhang, Wei,Li, Qizhai. AssocTests: An R Package for Genetic Association Studies[J]. JOURNAL OF STATISTICAL SOFTWARE,2020,94(5):1-26. |
| APA | Wang, Lin,Zhang, Wei,&Li, Qizhai.(2020).AssocTests: An R Package for Genetic Association Studies.JOURNAL OF STATISTICAL SOFTWARE,94(5),1-26. |
| MLA | Wang, Lin,et al."AssocTests: An R Package for Genetic Association Studies".JOURNAL OF STATISTICAL SOFTWARE 94.5(2020):1-26. |
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