AssocTests: An R Package for Genetic Association Studies

doi:10.18637/iss.v04.i05

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	AssocTests: An R Package for Genetic Association Studies
	Wang, Lin 1; Zhang, Wei 2; Li, Qizhai 2,3
	2020-06-01
发表期刊	JOURNAL OF STATISTICAL SOFTWARE
ISSN	1548-7660
卷号	94 期号:5 页码:1-26
摘要	The R package AssocTests provides some procedures which are commonly used in genetic association studies. These procedures are population stratification correction through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance regression, single-marker test, maximum test based on three Cochran-Armitage trend tests, non-parametric trend test, and non-parametric maximum test. The trait values for these methods should be discrete or continuous. The discrete traits can be coded by 1/0 for cases/controls. The genotype values can be 0, 1, or 2 indicating the number of risk alleles for a biallelic single-nucleotide polymorphism. This article introduces the methods and algorithms implemented in the package. Some examples are provided to illustrate the package's capability.
关键词	distance regression genetic association studies population stratification Tracy-Widom test R
DOI	10.18637/iss.v04.i05
收录类别	SCI
语种	英语
资助项目	Special National Key Research and Development Plan[2016YFD0400206] ; Beijing Natural Science Foundation[Z180006] ; National Science Foundation of China[11722113] ; National Nature Science Foundation of China[11701391] ; Scientific Research Level Improvement Quota Project of Capital University of Economics and Business ; 100 Talents Program of The Chinese Academy of Sciences for Young Scholars ; National Institutes of Health[NO1-AR-2-2263] ; National Institutes of Health[RO1-AR-44422] ; National Arthritis Foundation
WOS研究方向	Computer Science ; Mathematics
WOS类目	Computer Science, Interdisciplinary Applications ; Statistics & Probability
WOS记录号	WOS:000552355700001
出版者	JOURNAL STATISTICAL SOFTWARE
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/51859
专题	中国科学院数学与系统科学研究院
通讯作者	Li, Qizhai
作者单位	1.Capital Univ Econ & Business, Sch Stat, 121 Zhangjialukou, Beijing 100070, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, LSC, 55 Zhongguancun East Rd, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lin,Zhang, Wei,Li, Qizhai. AssocTests: An R Package for Genetic Association Studies[J]. JOURNAL OF STATISTICAL SOFTWARE,2020,94(5):1-26.
APA	Wang, Lin,Zhang, Wei,&Li, Qizhai.(2020).AssocTests: An R Package for Genetic Association Studies.JOURNAL OF STATISTICAL SOFTWARE,94(5),1-26.
MLA	Wang, Lin,et al."AssocTests: An R Package for Genetic Association Studies".JOURNAL OF STATISTICAL SOFTWARE 94.5(2020):1-26.