KMS Of Academy of mathematics and systems sciences, CAS
| IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations | |
Wang, Qi1,2; Yan, Guiying1,2
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| 2019-12-06 | |
| Source Publication | FRONTIERS IN GENETICS
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| Volume | 10Pages:10 |
| Abstract | It has been demonstrated that long non-coding RNAs (lncRNAs) play important roles in a variety of biological processes associated with human diseases. However, the identification of lncRNA-disease associations by experimental methods is time-consuming and labor-intensive. Computational methods provide an effective strategy to predict more potential lncRNA-disease associations to some degree. Based on the hypothesis that phenotypically similar diseases are often associated with functionally similar lncRNAs and vice versa, we developed an improved diffusion model to predict potential lncRNA-disease associations (IDLDA). As a result, our model performed well in the global and local cross-validations, which indicated that IDLDA had a great performance in predicting novel associations. Case studies of colon cancer, breast cancer, and gastric cancer were also implemented, all lncRNAs which ranked top 10 in both databases were verified by databases and related literature. The results showed that IDLDA might play a key role in biomedical research. |
| Keyword | long non-coding RNA disease association prediction computational prediction model diffusion model |
| DOI | 10.3389/fgene.2019.01259 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[11631014] |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000504209400001 |
| Publisher | FRONTIERS MEDIA SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/50458 |
| Collection | 应用数学研究所 |
| Corresponding Author | Yan, Guiying |
| Affiliation | 1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Qi,Yan, Guiying. IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations[J]. FRONTIERS IN GENETICS,2019,10:10. |
| APA | Wang, Qi,&Yan, Guiying.(2019).IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations.FRONTIERS IN GENETICS,10,10. |
| MLA | Wang, Qi,et al."IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations".FRONTIERS IN GENETICS 10(2019):10. |
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