IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations

doi:10.3389/fgene.2019.01259

CSpace > 应用数学研究所

	IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations
	Wang, Qi 1,2; Yan, Guiying1,2
	2019-12-06
发表期刊	FRONTIERS IN GENETICS
卷号	10 页码:10
摘要	It has been demonstrated that long non-coding RNAs (lncRNAs) play important roles in a variety of biological processes associated with human diseases. However, the identification of lncRNA-disease associations by experimental methods is time-consuming and labor-intensive. Computational methods provide an effective strategy to predict more potential lncRNA-disease associations to some degree. Based on the hypothesis that phenotypically similar diseases are often associated with functionally similar lncRNAs and vice versa, we developed an improved diffusion model to predict potential lncRNA-disease associations (IDLDA). As a result, our model performed well in the global and local cross-validations, which indicated that IDLDA had a great performance in predicting novel associations. Case studies of colon cancer, breast cancer, and gastric cancer were also implemented, all lncRNAs which ranked top 10 in both databases were verified by databases and related literature. The results showed that IDLDA might play a key role in biomedical research.
关键词	long non-coding RNA disease association prediction computational prediction model diffusion model
DOI	10.3389/fgene.2019.01259
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[11631014]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000504209400001
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/50458
专题	应用数学研究所
通讯作者	Yan, Guiying
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qi,Yan, Guiying. IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations[J]. FRONTIERS IN GENETICS,2019,10:10.
APA	Wang, Qi,&Yan, Guiying.(2019).IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations.FRONTIERS IN GENETICS,10,10.
MLA	Wang, Qi,et al."IDLDA: An Improved Diffusion Model for Predicting LncRNA-Disease Associations".FRONTIERS IN GENETICS 10(2019):10.