substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback

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	substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback
	Wu Lulu 1; Wang Pei 2; Lu Jinhu1
	2018
发表期刊	sciencechinatechnologicalsciences
ISSN	1674-7321
卷号	61 期号:8 页码:1175
摘要	In gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activation loops are ubiquitous regulatory motifs. This paper aims to investigate a two-component dual-positive feedback genetic circuit, which consists of a double negative feedback circuit and an additional positive feedback loop (APFL). We study effect of substrate concentration on gene expression in the single and the networked systems with APFLs, respectively. We find that substrate concentration can tune stochastic switch behavior in the signal system and then we explore relationship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we also discuss gene expression and stochastic switch behavior in the networked systems with APFLs. Based on analysis in the networked systems, we discover that genes express in some specific cells and do not express in the other cells when the expression achieves its steady state. These results can be used to well explain the character of regionalization in the expression of genes and the phenomenon of gene differentiation.
语种	英语
资助项目	[National Key Research and Development Program of China] ; [National Natural Science Foundation of China]
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/44980
专题	系统科学研究所
作者单位	1.中国科学院数学与系统科学研究院 2.河南大学
推荐引用方式 GB/T 7714	Wu Lulu,Wang Pei,Lu Jinhu. substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback[J]. sciencechinatechnologicalsciences,2018,61(8):1175.
APA	Wu Lulu,Wang Pei,&Lu Jinhu.(2018).substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback.sciencechinatechnologicalsciences,61(8),1175.
MLA	Wu Lulu,et al."substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback".sciencechinatechnologicalsciences 61.8(2018):1175.