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Wu Lulu1; Wang Pei2; Lu Jinhu1
Source Publicationsciencechinatechnologicalsciences
AbstractIn gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activation loops are ubiquitous regulatory motifs. This paper aims to investigate a two-component dual-positive feedback genetic circuit, which consists of a double negative feedback circuit and an additional positive feedback loop (APFL). We study effect of substrate concentration on gene expression in the single and the networked systems with APFLs, respectively. We find that substrate concentration can tune stochastic switch behavior in the signal system and then we explore relationship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we also discuss gene expression and stochastic switch behavior in the networked systems with APFLs. Based on analysis in the networked systems, we discover that genes express in some specific cells and do not express in the other cells when the expression achieves its steady state. These results can be used to well explain the character of regionalization in the expression of genes and the phenomenon of gene differentiation.
Funding Project[National Key Research and Development Program of China] ; [National Natural Science Foundation of China]
Document Type期刊论文
Recommended Citation
GB/T 7714
Wu Lulu,Wang Pei,Lu Jinhu. substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback[J]. sciencechinatechnologicalsciences,2018,61(8):1175.
APA Wu Lulu,Wang Pei,&Lu Jinhu.(2018).substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback.sciencechinatechnologicalsciences,61(8),1175.
MLA Wu Lulu,et al."substrateconcentrationeffectongeneexpressioningeneticcircuitswithadditionalpositivefeedback".sciencechinatechnologicalsciences 61.8(2018):1175.
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