Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects

doi:10.1016/j.neulet.2007.01.056

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	Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects
	Yue, Weihua ; Kang, Guolian ; Zhang, Yanbo ; Qu, Mei ; Tang, Fulei ; Han, Yonghua ; Ruan, Yan ; Lu, Tianlan ; Zhang, Jifeng ; Zhang, Dai
	2007-04-06
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	416 期号:1 页码:96-100
摘要	The present study examined the correlation between variants in the D-amino acid oxidase activator (DAOA) locus and clinical symptoms and response to antipsychotics in schizophrenia. Case-control analysis and the family-based association test (FBAT) were performed to investigate whether four single nucleotide polymorphisms (SNPs) at DAOA gene are associated with schizophrenia. The association between the DAOA risk haplotype and clinical symptoms were examined by the positive and negative syndrome scale (PANSS) and the brief psychiatric rating scale (BPRS). Our findings showed that the SNP rs947267 was significantly associated with schizophrenia in both case control and familial trio samples (A > C, x(2) = 8.36, p = 0.004; Z= 2.335, p = 0.019), as well as with specific haplotypes, in particular those formed by the A allele of rs947267. In addition, the risk haplotype AAG was significantly correlated with negative, depression and cognitive impairment factors of PANSS, even with the BPRS change scores after 6-week treatment of atypical antipsychotic drugs (p < 0.05). These results support the hypothesis that variations in DAOA may play a role in schizophrenia and clinical characteristics. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
关键词	schizophrenia DAOA association study clinical symptom therapeutic effect
DOI	10.1016/j.neulet.2007.01.056
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000246038900019
出版者	ELSEVIER IRELAND LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/4277
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Dai
作者单位	1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Michigan State Univ, Dept Probabil & Stat, E Lansing, MI 48824 USA
推荐引用方式 GB/T 7714	Yue, Weihua,Kang, Guolian,Zhang, Yanbo,et al. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects[J]. NEUROSCIENCE LETTERS,2007,416(1):96-100.
APA	Yue, Weihua.,Kang, Guolian.,Zhang, Yanbo.,Qu, Mei.,Tang, Fulei.,...&Zhang, Dai.(2007).Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects.NEUROSCIENCE LETTERS,416(1),96-100.
MLA	Yue, Weihua,et al."Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects".NEUROSCIENCE LETTERS 416.1(2007):96-100.