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A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment
Zhang, Wei1; Liu, Aiyi1; Tang, Larry L.2,3; Li, Qizhai4
2019-09-01
Source PublicationBIOMETRICS
ISSN0006-341X
Volume75Issue:3Pages:821-830
AbstractMultiple endpoints are often naturally clustered based on their scientific interpretations. Tests that compare these clustered outcomes between independent groups may lose efficiency if the cluster structures are not properly accounted for. For the two-sample generalized Behrens-Fisher hypothesis concerning multiple endpointswe propose a cluster-adjusted multivariate test procedure for the comparison and demonstrate its gain in efficiency over test procedures that ignore the clusters. Data from a dietary intervention trial are used to illustrate the methods.
Keywordgeneralized Behrens-Fisher hypothesis multivariate distributions nonparametrics rank statistics type I errors power of test
DOI10.1111/biom.13029
Language英语
Funding ProjectIntramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health ; Intramural Research Program of the National Institutes of Health ; US Social Security Administration ; Special National Key Research and Development Plan[2016YFD0400206] ; Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences[XDB13040600] ; National Nature Science Foundation of China[11722113]
WOS Research AreaLife Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology ; Mathematics
WOS SubjectBiology ; Mathematical & Computational Biology ; Statistics & Probability
WOS IDWOS:000488608100010
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/35874
Collection系统科学研究所
Corresponding AuthorLi, Qizhai
Affiliation1.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD USA
2.George Mason Univ, Dept Stat, Fairfax, VA 22030 USA
3.Natl Inst Hlth Clin Ctr, Rehabil Med Dept, Bethesda, MD USA
4.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Wei,Liu, Aiyi,Tang, Larry L.,et al. A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment[J]. BIOMETRICS,2019,75(3):821-830.
APA Zhang, Wei,Liu, Aiyi,Tang, Larry L.,&Li, Qizhai.(2019).A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment.BIOMETRICS,75(3),821-830.
MLA Zhang, Wei,et al."A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment".BIOMETRICS 75.3(2019):821-830.
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