KMS Of Academy of mathematics and systems sciences, CAS
| A Powerful Method To Test Associations Between Ordinal Traits and Genotypes | |
Wang, Jinjuan1,2; Ding, Juan3; Huang, Shouyou4; Li, Qizhai1 ; Pan, Dongdong5,6
| |
| 2019-08-01 | |
| Source Publication | G3-GENES GENOMES GENETICS
 |
| ISSN | 2160-1836 |
| Volume | 9Issue:8Pages:2573-2579 |
| Abstract | The methods commonly used to test the associations between ordinal phenotypes and genotypes often treat either the ordinal phenotype or the genotype as continuous variables. To address limitations of these approaches, we propose a model where both the ordinal phenotype and the genotype are viewed as manifestations of an underlying multivariate normal random variable. The proposed method allows modeling the ordinal phenotype, the genotype and covariates jointly. We employ the generalized estimating equation technique and M-estimation theory to estimate the model parameters and deduce the corresponding asymptotic distribution. Numerical simulations and real data applications are also conducted to compare the performance of the proposed method with those of methods based on the logit and probit models. Even though there may be potential limitations in Type I error rate control for our method, the gains in power can prove its practical value in case of exactly ordinal phenotypes. |
| Keyword | association study ordinal phenotype latent normal variate generalized estimating equation M-estimation |
| DOI | 10.1534/g3.119.400293 |
| Language | 英语 |
| Funding Project | Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; National Nature Science Foundation of China[11661080] ; National Nature Science Foundation of China[11731011] ; National Nature Science Foundation of China[11501134] ; Applied Basic Research Project of Yunnan Province[2017FB002] ; Science and Technology Research Project of the Education Department in Hubei Province[Q20172505] |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000479303300018 |
| Publisher | GENETICS SOCIETY AMERICA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/35461 |
| Collection | 系统科学研究所 |
| Corresponding Author | Li, Qizhai; Pan, Dongdong |
| Affiliation | 1.Chinese Acad Sci, Acad Math & Syst Sci, LSC, NCMIS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangxi Normal Univ, Sch Math & Stat, Guilin 541004, Peoples R China 4.Hubei Normal Univ, Sch Math & Stat, Huangshi 435002, Hubei, Peoples R China 5.Yunnan Univ, Yunnan Key Lab Stat Modeling & Data Anal, Kunming 650500, Yunnan, Peoples R China 6.Yale Univ, Dept Biostat, Sch Publ Hlth, New Haven, CT 06511 USA |
| Recommended Citation GB/T 7714 | Wang, Jinjuan,Ding, Juan,Huang, Shouyou,et al. A Powerful Method To Test Associations Between Ordinal Traits and Genotypes[J]. G3-GENES GENOMES GENETICS,2019,9(8):2573-2579. |
| APA | Wang, Jinjuan,Ding, Juan,Huang, Shouyou,Li, Qizhai,&Pan, Dongdong.(2019).A Powerful Method To Test Associations Between Ordinal Traits and Genotypes.G3-GENES GENOMES GENETICS,9(8),2573-2579. |
| MLA | Wang, Jinjuan,et al."A Powerful Method To Test Associations Between Ordinal Traits and Genotypes".G3-GENES GENOMES GENETICS 9.8(2019):2573-2579. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment