A Powerful Method To Test Associations Between Ordinal Traits and Genotypes

doi:10.1534/g3.119.400293

CSpace > 系统科学研究所

	A Powerful Method To Test Associations Between Ordinal Traits and Genotypes
	Wang, Jinjuan 1,2; Ding, Juan 3; Huang, Shouyou 4; Li, Qizhai1 ; Pan, Dongdong 5,6
	2019-08-01
发表期刊	G3-GENES GENOMES GENETICS
ISSN	2160-1836
卷号	9 期号:8 页码:2573-2579
摘要	The methods commonly used to test the associations between ordinal phenotypes and genotypes often treat either the ordinal phenotype or the genotype as continuous variables. To address limitations of these approaches, we propose a model where both the ordinal phenotype and the genotype are viewed as manifestations of an underlying multivariate normal random variable. The proposed method allows modeling the ordinal phenotype, the genotype and covariates jointly. We employ the generalized estimating equation technique and M-estimation theory to estimate the model parameters and deduce the corresponding asymptotic distribution. Numerical simulations and real data applications are also conducted to compare the performance of the proposed method with those of methods based on the logit and probit models. Even though there may be potential limitations in Type I error rate control for our method, the gains in power can prove its practical value in case of exactly ordinal phenotypes.
关键词	association study ordinal phenotype latent normal variate generalized estimating equation M-estimation
DOI	10.1534/g3.119.400293
语种	英语
资助项目	Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; National Nature Science Foundation of China[11661080] ; National Nature Science Foundation of China[11731011] ; National Nature Science Foundation of China[11501134] ; Applied Basic Research Project of Yunnan Province[2017FB002] ; Science and Technology Research Project of the Education Department in Hubei Province[Q20172505]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000479303300018
出版者	GENETICS SOCIETY AMERICA
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/35461
专题	系统科学研究所
通讯作者	Li, Qizhai; Pan, Dongdong
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, LSC, NCMIS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Guangxi Normal Univ, Sch Math & Stat, Guilin 541004, Peoples R China 4.Hubei Normal Univ, Sch Math & Stat, Huangshi 435002, Hubei, Peoples R China 5.Yunnan Univ, Yunnan Key Lab Stat Modeling & Data Anal, Kunming 650500, Yunnan, Peoples R China 6.Yale Univ, Dept Biostat, Sch Publ Hlth, New Haven, CT 06511 USA
推荐引用方式 GB/T 7714	Wang, Jinjuan,Ding, Juan,Huang, Shouyou,et al. A Powerful Method To Test Associations Between Ordinal Traits and Genotypes[J]. G3-GENES GENOMES GENETICS,2019,9(8):2573-2579.
APA	Wang, Jinjuan,Ding, Juan,Huang, Shouyou,Li, Qizhai,&Pan, Dongdong.(2019).A Powerful Method To Test Associations Between Ordinal Traits and Genotypes.G3-GENES GENOMES GENETICS,9(8),2573-2579.
MLA	Wang, Jinjuan,et al."A Powerful Method To Test Associations Between Ordinal Traits and Genotypes".G3-GENES GENOMES GENETICS 9.8(2019):2573-2579.