Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes

doi:10.3389/fgene.2019.00252

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	Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes
	Sun, Shaoyan 1; Sung, Fengnan 2; Wang, Yong3,4
	2019-03-26
发表期刊	FRONTIERS IN GENETICS
ISSN	1664-8021
卷号	10 页码:16
摘要	Type 2 diabetes (T2D) is known as a disease caused by gene alterations characterized by insulin resistance, thus the insulin-responsive tissues are of great interest for T2D study. It's of great relevance to systematically investigate commonalities and specificities of T2D among those tissues. Here we establish a multi-level comparative framework across three insulin target tissues (white adipose, skeletal muscle, and liver) to provide a better understanding of T2D. Starting from the ranks of gene expression, we constructed the 'disease network' through detecting diverse interactions to provide a well-characterization for disease affected tissues. Then, we applied random walk with restart algorithm to the disease network to prioritize its nodes and edges according to their association with T2D. Finally, we identified a merged core module by combining the clustering coefficient and Jaccard index, which can provide elaborate and visible illumination of the common and specific features for different tissues at network level. Taken together, our network-, gene-, and module-level characterization across different tissues of T2D hold the promise to provide a broader and deeper understanding for T2D mechanism.
关键词	type 2 diabetes gene pairwise expression dysfunctional interactions multi-level analysis random walk with restart
DOI	10.3389/fgene.2019.00252
语种	英语
资助项目	National Key Research and Development Program of China[2017YFC0908400] ; NSFC[11871463] ; NSFC[61621003] ; NSFC[61671444]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000462601100003
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/34275
专题	应用数学研究所
通讯作者	Sun, Shaoyan; Wang, Yong
作者单位	1.Ludong Univ, Sch Math & Stat, Yenta, Peoples R China 2.Yantaishan Hosp, Clin Lab, Yantai, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, CEMS,NCMIS, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Sun, Shaoyan,Sung, Fengnan,Wang, Yong. Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes[J]. FRONTIERS IN GENETICS,2019,10:16.
APA	Sun, Shaoyan,Sung, Fengnan,&Wang, Yong.(2019).Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes.FRONTIERS IN GENETICS,10,16.
MLA	Sun, Shaoyan,et al."Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes".FRONTIERS IN GENETICS 10(2019):16.