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Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes
Sun, Shaoyan1; Sung, Fengnan2; Wang, Yong3,4
2019-03-26
Source PublicationFRONTIERS IN GENETICS
ISSN1664-8021
Volume10Pages:16
AbstractType 2 diabetes (T2D) is known as a disease caused by gene alterations characterized by insulin resistance, thus the insulin-responsive tissues are of great interest for T2D study. It's of great relevance to systematically investigate commonalities and specificities of T2D among those tissues. Here we establish a multi-level comparative framework across three insulin target tissues (white adipose, skeletal muscle, and liver) to provide a better understanding of T2D. Starting from the ranks of gene expression, we constructed the 'disease network' through detecting diverse interactions to provide a well-characterization for disease affected tissues. Then, we applied random walk with restart algorithm to the disease network to prioritize its nodes and edges according to their association with T2D. Finally, we identified a merged core module by combining the clustering coefficient and Jaccard index, which can provide elaborate and visible illumination of the common and specific features for different tissues at network level. Taken together, our network-, gene-, and module-level characterization across different tissues of T2D hold the promise to provide a broader and deeper understanding for T2D mechanism.
Keywordtype 2 diabetes gene pairwise expression dysfunctional interactions multi-level analysis random walk with restart
DOI10.3389/fgene.2019.00252
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFC0908400] ; NSFC[11871463] ; NSFC[61621003] ; NSFC[61671444]
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000462601100003
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/34275
Collection应用数学研究所
Corresponding AuthorSun, Shaoyan; Wang, Yong
Affiliation1.Ludong Univ, Sch Math & Stat, Yenta, Peoples R China
2.Yantaishan Hosp, Clin Lab, Yantai, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, MDIS, CEMS,NCMIS, Beijing, Peoples R China
4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Sun, Shaoyan,Sung, Fengnan,Wang, Yong. Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes[J]. FRONTIERS IN GENETICS,2019,10:16.
APA Sun, Shaoyan,Sung, Fengnan,&Wang, Yong.(2019).Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes.FRONTIERS IN GENETICS,10,16.
MLA Sun, Shaoyan,et al."Multi-Level Comparative Framework Based on Gene Pair-Wise Expression Across Three Insulin Target Tissues for Type 2 Diabetes".FRONTIERS IN GENETICS 10(2019):16.
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