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Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event
Sun, Xiaowei1,2; Sun, Liuquan1,2
2019
Source PublicationSTATISTICS AND ITS INTERFACE
ISSN1938-7989
Volume12Issue:1Pages:1-9
AbstractRecurrent event data often arise from biomedical studies and a terminal event may preclude further occurrence of recurrent events. In comparing treatments, the marginal mean is frequently of interest, and treatment-specific differences in the mean number of events are often not constant over time. In this article, we propose a semiparametric method to compare treatment-specific recurrent event means by combining an additive hazards model for the terminal event and an additive rates model for the conditional recurrent event rate. The treatment effect is measured by the difference between treatment-specific recurrent event means. Estimation procedures are developed for the measure and the asymptotic properties of the proposed estimators are established. The finite sample performance of the proposed estimators is examined through simulation studies, and an application to a bladder cancer study demonstrates the usefulness of our method.
KeywordAdditive models Marginal mean Recurrent events Semiparametric method Terminal event Treatment effect
Language英语
Funding ProjectNational Natural Science Foundation of China[11771431] ; National Natural Science Foundation of China[11690015] ; Key Laboratory of RCSDS, CAS[2008DP173182]
WOS Research AreaMathematical & Computational Biology ; Mathematics
WOS SubjectMathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS IDWOS:000460758600001
PublisherINT PRESS BOSTON, INC
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Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/34194
Collection应用数学研究所
Corresponding AuthorSun, Liuquan
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Sun, Xiaowei,Sun, Liuquan. Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event[J]. STATISTICS AND ITS INTERFACE,2019,12(1):1-9.
APA Sun, Xiaowei,&Sun, Liuquan.(2019).Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event.STATISTICS AND ITS INTERFACE,12(1),1-9.
MLA Sun, Xiaowei,et al."Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event".STATISTICS AND ITS INTERFACE 12.1(2019):1-9.
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