Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event

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	Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event
	Sun, Xiaowei 1,2; Sun, Liuquan1,2
	2019
发表期刊	STATISTICS AND ITS INTERFACE
ISSN	1938-7989
卷号	12 期号:1 页码:1-9
摘要	Recurrent event data often arise from biomedical studies and a terminal event may preclude further occurrence of recurrent events. In comparing treatments, the marginal mean is frequently of interest, and treatment-specific differences in the mean number of events are often not constant over time. In this article, we propose a semiparametric method to compare treatment-specific recurrent event means by combining an additive hazards model for the terminal event and an additive rates model for the conditional recurrent event rate. The treatment effect is measured by the difference between treatment-specific recurrent event means. Estimation procedures are developed for the measure and the asymptotic properties of the proposed estimators are established. The finite sample performance of the proposed estimators is examined through simulation studies, and an application to a bladder cancer study demonstrates the usefulness of our method.
关键词	Additive models Marginal mean Recurrent events Semiparametric method Terminal event Treatment effect
语种	英语
资助项目	National Natural Science Foundation of China[11771431] ; National Natural Science Foundation of China[11690015] ; Key Laboratory of RCSDS, CAS[2008DP173182]
WOS研究方向	Mathematical & Computational Biology ; Mathematics
WOS类目	Mathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS记录号	WOS:000460758600001
出版者	INT PRESS BOSTON, INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/34194
专题	应用数学研究所
通讯作者	Sun, Liuquan
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Sun, Xiaowei,Sun, Liuquan. Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event[J]. STATISTICS AND ITS INTERFACE,2019,12(1):1-9.
APA	Sun, Xiaowei,&Sun, Liuquan.(2019).Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event.STATISTICS AND ITS INTERFACE,12(1),1-9.
MLA	Sun, Xiaowei,et al."Semiparametric estimation of differences in treatment-specific recurrent event means with a terminal event".STATISTICS AND ITS INTERFACE 12.1(2019):1-9.