"Brain Connectivity Deviates by Sex and Hemisphere in the First Episode of Schizophrenia"A Route to the Genetic Basis of Language and Psychosis?

doi:10.1093/schbul/sby061

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	"Brain Connectivity Deviates by Sex and Hemisphere in the First Episode of Schizophrenia"A Route to the Genetic Basis of Language and Psychosis?
	Wang, Qiang 1,2,3; Zhang, Jie 4,5; Liu, Zhaowen 6,7,8; Crow, Tim J.9; Zhang, Kai 10; Palaniyappan, Lena 11,12,13; Li, Mingli 1,2,3; Zhao, Liansheng 1,2,3; Li, Xiaojing 1,2,3; Deng, Wei 1,2,3; Guo, Wanjun 1,2,3; Ma, Xiaohong 1,2,3; Cheng, Wei 4,5; Ma, Liang 14; Wan, Lin9,15 ; Lu, Guangming 10,16; Liu, Zhening 17; Wang, Jijun 18; Feng, Jianfeng 4,5,19,20,21,22; Li, Tao 1,2,3
	2019-03-01
发表期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
卷号	45 期号:2 页码:484-494
摘要	Schizophrenia is genetic in origin and associated with a fecundity disadvantage. The deficits in schizophrenia have been attributed to variation related to the human capacity for language or brain laterality. How sex influences the relative connectivity of the 2 hemispheres is a route to understanding these 2 functions. Using resting-state functional magnetic resonance imaging (fMRI) we searched for sex- and hemisphere-specific changes in whole-brain functional-connectivity in multi-site datasets (altogether 672 subjects including 286 patients, all right-handed) in the first-episode schizophrenia (illness duration 1 year, mostly drug naive) and in chronic stages of schizophrenia (illness duration > 1 year), respectively. We used meta-analyses to integrate data from different sources concerning individuals at the same illness stage. We found first-episode male patients are predominantly left-lateralized in aberrant connectivity with a focus on Broca's area. Female patients show a lesser degree of lateralization than males, but to the right particularly in orbital frontal cortex. In the chronic stage, the focus of aberrant connectivity shifted from anterior to posterior structures with prominent involvement of the thalamus and pre- and post-central gyri bilaterally and in both sexes. While the deviant connectivity is right-sided in both the first-episode and the chronic stages in females, in males there is a shift between stages from the left to the right hemisphere. We hypothesized that the pathophysiology of schizophrenia may lie in the interaction between sex and lateralization, ie, in genetic mechanisms located on the X and Y chromosomes, intrinsic to the evolution of language.
关键词	resting-state fMRI whole-brain functional connectivity analysis sex-effect lateralization language PCDH11XY sexual selection
DOI	10.1093/schbul/sby061
语种	英语
资助项目	National High Technology Research and Development Program of China[2015AA020507] ; Key Project of Shanghai Science & Technology Innovation Plan[15JC1400101] ; National Centre for Mathematics and Interdisciplinary Sciences (NCMIS) of the Chinese Academy of Sciences ; National Natural Science Foundation of China[91230201] ; National Natural Science Foundation of China[81630030] ; National Natural Science Foundation of China[81771446] ; National Science Foundation of China[NSFC 81771446] ; National Science Foundation of China[NSFC 61573107] ; special Funds for Major State Basic Research Projects of China[2015CB856003] ; National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme[81461168029] ; National Key Research and Development Program of the Ministry of Science and Technology of China[2016YFC0904300] ; 1.3.5 Project for Disciplines of Excellence, West China Hospital of Sichuan University[ZY2016103] ; 1.3.5 Project for Disciplines of Excellence, West China Hospital of Sichuan University[ZY2016203] ; Shanghai Science and Technology Committee[14411961400] ; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, PR China ; Taiwan Ministry of Science and Technology[NSC99-3112-B-002-030]
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000461163300027
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/34141
专题	系统科学研究所
通讯作者	Feng, Jianfeng; Li, Tao
作者单位	1.Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China 2.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Psychiat Lab, Chengdu 610041, Sichuan, Peoples R China 3.Sichuan Univ, West China Hosp, West China Brain Res Ctr, Chengdu, Sichuan, Peoples R China 4.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China 5.Fudan Univ, Minist Educ, Key Lab Computat Neurosci & BrainInspired Intelli, Shanghai, Peoples R China 6.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian, Shaanxi, Peoples R China 7.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Shaanxi, Peoples R China 8.Xidian Univ, Sch Comp Sci & Technol, Xian, Shaanxi, Peoples R China 9.Warneford Hosp, Univ Dept Psychiat, POWIC, Oxford, England 10.Temple Univ, Dept Comp & Informat Sci, Philadelphia, PA 19122 USA 11.Univ Western Ontario, Robarts Res Inst, London, ON, Canada 12.Lawson Hlth Res Inst, London, ON, Canada 13.Univ Nottingham, Inst Mental Hlth, Ctr Translat Neuroimaging, Nottingham, England 14.Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China 15.Chinese Acad Sci, Acad Math & Syst Sci, Interdisciplinary Sci, Beijing, Peoples R China 16.Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing, Jiangsu, Peoples R China 17.Cent S Univ, Xiangya Hosp, Mental Hlth Ctr, Changsha, Hunan, Peoples R China 18.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders 13dz2260500, Shanghai, Peoples R China 19.Univ Warwick, Dept Comp Sci, Coventry, W Midlands, England 20.Fudan Univ, Collaborat Innovat Ctr Brain Sci, Shanghai, Peoples R China 21.Shanghai Ctr Math Sci, Shanghai, Peoples R China 22.Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qiang,Zhang, Jie,Liu, Zhaowen,et al. "Brain Connectivity Deviates by Sex and Hemisphere in the First Episode of Schizophrenia"A Route to the Genetic Basis of Language and Psychosis?[J]. SCHIZOPHRENIA BULLETIN,2019,45(2):484-494.
APA	Wang, Qiang.,Zhang, Jie.,Liu, Zhaowen.,Crow, Tim J..,Zhang, Kai.,...&Li, Tao.(2019)."Brain Connectivity Deviates by Sex and Hemisphere in the First Episode of Schizophrenia"A Route to the Genetic Basis of Language and Psychosis?.SCHIZOPHRENIA BULLETIN,45(2),484-494.
MLA	Wang, Qiang,et al.""Brain Connectivity Deviates by Sex and Hemisphere in the First Episode of Schizophrenia"A Route to the Genetic Basis of Language and Psychosis?".SCHIZOPHRENIA BULLETIN 45.2(2019):484-494.