Inferring protein interactions from experimental data by association probabilistic method

doi:10.1002/prot.20783

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	Inferring protein interactions from experimental data by association probabilistic method
	Chen, LN ; Wu, LY; Wang, Y; Zhang, XS
	2006-03-01
发表期刊	PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
ISSN	0887-3585
卷号	62 期号:4 页码:833-837
摘要	To elucidate protein interaction networks is one of the major goals of functional genomics for whole organisms. So far, various computational methods have been proposed for inference of protein-protein interactions. Based on the association method by Sprinzak et al., we propose an association probabilistic method in this short communication to infer protein interactions directly from the experimental data, which outperformed other existing methods in terms of both accuracy and efficiency despite its simple form. Specifically, we show that the association probabilistic method achieves the highest accuracy among the existing approaches for the measures of root-mean-square error and the Pearson correlation coefficient, and also runs much faster than the LP-based method, by experimental dataset in Yeast. Software is available from the authors upon request.
关键词	protein interaction domain interaction protein network bioinformatics
DOI	10.1002/prot.20783
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000235872700001
出版者	WILEY-LISS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/3405
专题	应用数学研究所
通讯作者	Chen, LN
作者单位	1.Osaka Sangyo Univ, Osaka 5748530, Japan 2.CAS, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chen, LN,Wu, LY,Wang, Y,et al. Inferring protein interactions from experimental data by association probabilistic method[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2006,62(4):833-837.
APA	Chen, LN,Wu, LY,Wang, Y,&Zhang, XS.(2006).Inferring protein interactions from experimental data by association probabilistic method.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,62(4),833-837.
MLA	Chen, LN,et al."Inferring protein interactions from experimental data by association probabilistic method".PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 62.4(2006):833-837.