KMS Of Academy of mathematics and systems sciences, CAS
| Association of G72/G30 polymorphisms with early-onset and male schizophrenia | |
| Yue, Weihua; Liu, Zhonghua; Kang, Guolian; Yan, Jun; Tang, Fulei; Ruan, Yan; Zhang, Jifeng; Zhang, Dai | |
| 2006-12-18 | |
| Source Publication | NEUROREPORT
 |
| ISSN | 0959-4965 |
| Volume | 17Issue:18Pages:1899-1902 |
| Abstract | To explore the effect of G72/G30 polymorphisms on the clinical manifestations of schizophrenia, especially on the age at onset and sex of patients, we examined three single nucleotide polymorphisms in 216 schizophrenic patients and 321 healthy controls. Significant associations of schizophrenia with the A allele of rs947267 (P = 0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P = 0.008) were found in early-onset schizophrenic patients. So did the same allele (P = 0.034) and haplotype (P = 0.009) as mentioned above in male patients. These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia. |
| Keyword | age at onset association study G72/G30 polymorphism schizophrenia |
| Language | 英语 |
| WOS Research Area | Neurosciences & Neurology |
| WOS Subject | Neurosciences |
| WOS ID | WOS:000243538600013 |
| Publisher | LIPPINCOTT WILLIAMS & WILKINS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/3255 |
| Collection | 中国科学院数学与系统科学研究院 |
| Corresponding Author | Zhang, Dai |
| Affiliation | 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48824 USA |
| Recommended Citation GB/T 7714 | Yue, Weihua,Liu, Zhonghua,Kang, Guolian,et al. Association of G72/G30 polymorphisms with early-onset and male schizophrenia[J]. NEUROREPORT,2006,17(18):1899-1902. |
| APA | Yue, Weihua.,Liu, Zhonghua.,Kang, Guolian.,Yan, Jun.,Tang, Fulei.,...&Zhang, Dai.(2006).Association of G72/G30 polymorphisms with early-onset and male schizophrenia.NEUROREPORT,17(18),1899-1902. |
| MLA | Yue, Weihua,et al."Association of G72/G30 polymorphisms with early-onset and male schizophrenia".NEUROREPORT 17.18(2006):1899-1902. |
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