Association of G72/G30 polymorphisms with early-onset and male schizophrenia

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	Association of G72/G30 polymorphisms with early-onset and male schizophrenia
	Yue, Weihua ; Liu, Zhonghua ; Kang, Guolian ; Yan, Jun ; Tang, Fulei ; Ruan, Yan ; Zhang, Jifeng ; Zhang, Dai
	2006-12-18
发表期刊	NEUROREPORT
ISSN	0959-4965
卷号	17 期号:18 页码:1899-1902
摘要	To explore the effect of G72/G30 polymorphisms on the clinical manifestations of schizophrenia, especially on the age at onset and sex of patients, we examined three single nucleotide polymorphisms in 216 schizophrenic patients and 321 healthy controls. Significant associations of schizophrenia with the A allele of rs947267 (P = 0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P = 0.008) were found in early-onset schizophrenic patients. So did the same allele (P = 0.034) and haplotype (P = 0.009) as mentioned above in male patients. These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia.
关键词	age at onset association study G72/G30 polymorphism schizophrenia
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000243538600013
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/3255
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Dai
作者单位	1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48824 USA
推荐引用方式 GB/T 7714	Yue, Weihua,Liu, Zhonghua,Kang, Guolian,et al. Association of G72/G30 polymorphisms with early-onset and male schizophrenia[J]. NEUROREPORT,2006,17(18):1899-1902.
APA	Yue, Weihua.,Liu, Zhonghua.,Kang, Guolian.,Yan, Jun.,Tang, Fulei.,...&Zhang, Dai.(2006).Association of G72/G30 polymorphisms with early-onset and male schizophrenia.NEUROREPORT,17(18),1899-1902.
MLA	Yue, Weihua,et al."Association of G72/G30 polymorphisms with early-onset and male schizophrenia".NEUROREPORT 17.18(2006):1899-1902.