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TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment
Li, Lingjie1,2,4,5; Wang, Yong3,5,8,9; Torkelson, Jessica L.1,2,4; Shankar, Gautam1,2; Pattison, Jillian M.1,2,4; Zhen, Hanson H.1,2,4; Fang, Fengqin6; Duren, Zhana3,5,8; Xin, Jingxue3,5,8; Gaddam, Sadhana1,2,4; Melo, Sandra P.1,2; Piekos, Samantha N.1,2,4,7; Li, Jiang1,2; Liaw, Eric J.1,2; Chen, Lang; Li, Rui1,2,5; Wernig, Marius7; Wong, Wing H.3,5; Chang, Howard Y.1,2,5; Oro, Anthony E.1,2,4,7
2019-02-07
Source PublicationCELL STEM CELL
ISSN1934-5909
Volume24Issue:2Pages:271-+
AbstractTissue development results from lineage-specific transcription factors (TFs) programming a dynamic chromatin landscape through progressive cell fate transitions. Here, we define epigenomic landscape during epidermal differentiation of human pluripotent stem cells (PSCs) and create inference networks that integrate gene expression, chromatin accessibility, and TF binding to define regulatory mechanisms during keratinocyte specification. We found two critical chromatin networks during surface ectoderm initiation and keratinocyte maturation, which are driven by TFAP2C and p63, respectively. Consistently, TFAP2C, but not p63, is sufficient to initiate surface ectoderm differentiation, and TFAP2C-initiated progenitor cells are capable of maturing into functional keratinocytes. Mechanistically, TFAP2C primes the surface ectoderm chromatin landscape and induces p63 expression and binding sites, thus allowing maturation factor p63 to positively autoregulate its own expression and close a subset of the TFAP2-Cinitiated surface ectoderm program. Our work provides a general framework to infer TF networks controlling chromatin transitions that will facilitate future regenerative medicine advances.
DOI10.1016/j.stem.2018.12.012
Language英语
Funding ProjectNIH[P50-HG007735] ; NIH[R01GM109836] ; NIH[F32AR070565] ; California Institute for Regenerative Medicine tools[RT3-07796] ; National Natural Science Foundation of China[61671444] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[91730301] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13000000] ; EB Research Partnership
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000458027300013
PublisherCELL PRESS
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/32522
Collection中国科学院数学与系统科学研究院
Affiliation1.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA
2.Stanford Univ, Dept Dermatol, Sch Med, Stanford, CA 94305 USA
3.Stanford Univ, Dept Stat & Biomed Data Sci, Sch Med, Stanford, CA 94305 USA
4.Stanford Univ, Ctr Definit & Curat Med, Sch Med, Stanford, CA 94305 USA
5.Stanford Univ, Ctr Personal Dynam Regulome, Sch Med, Stanford, CA 94305 USA
6.Stanford Univ, Div Immunol & Rheumatol, Dept Med, Sch Med, Stanford, CA 94305 USA
7.Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Dept Pathol, Sch Med, Stanford, CA 94305 USA
8.Chinese Acad Sci, CEMS, NCMIS, MDIS,Acad Math & Syst Sci, Beijing 100080, Peoples R China
9.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Lingjie,Wang, Yong,Torkelson, Jessica L.,et al. TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment[J]. CELL STEM CELL,2019,24(2):271-+.
APA Li, Lingjie.,Wang, Yong.,Torkelson, Jessica L..,Shankar, Gautam.,Pattison, Jillian M..,...&Oro, Anthony E..(2019).TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.CELL STEM CELL,24(2),271-+.
MLA Li, Lingjie,et al."TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment".CELL STEM CELL 24.2(2019):271-+.
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