TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment

doi:10.1016/j.stem.2018.12.012

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	TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment
	Li, Lingjie 1,2,4,5; Wang, Yong3,5,8,9 ; Torkelson, Jessica L.1,2,4; Shankar, Gautam 1,2; Pattison, Jillian M.1,2,4; Zhen, Hanson H.1,2,4; Fang, Fengqin 6; Duren, Zhana 3,5,8; Xin, Jingxue 3,5,8; Gaddam, Sadhana 1,2,4; Melo, Sandra P.1,2; Piekos, Samantha N.1,2,4,7; Li, Jiang 1,2; Liaw, Eric J.1,2; Chen, Lang ; Li, Rui 1,2,5; Wernig, Marius 7; Wong, Wing H.3,5; Chang, Howard Y.1,2,5; Oro, Anthony E.1,2,4,7
	2019-02-07
发表期刊	CELL STEM CELL
ISSN	1934-5909
卷号	24 期号:2 页码:271-+
摘要	Tissue development results from lineage-specific transcription factors (TFs) programming a dynamic chromatin landscape through progressive cell fate transitions. Here, we define epigenomic landscape during epidermal differentiation of human pluripotent stem cells (PSCs) and create inference networks that integrate gene expression, chromatin accessibility, and TF binding to define regulatory mechanisms during keratinocyte specification. We found two critical chromatin networks during surface ectoderm initiation and keratinocyte maturation, which are driven by TFAP2C and p63, respectively. Consistently, TFAP2C, but not p63, is sufficient to initiate surface ectoderm differentiation, and TFAP2C-initiated progenitor cells are capable of maturing into functional keratinocytes. Mechanistically, TFAP2C primes the surface ectoderm chromatin landscape and induces p63 expression and binding sites, thus allowing maturation factor p63 to positively autoregulate its own expression and close a subset of the TFAP2-Cinitiated surface ectoderm program. Our work provides a general framework to infer TF networks controlling chromatin transitions that will facilitate future regenerative medicine advances.
DOI	10.1016/j.stem.2018.12.012
语种	英语
资助项目	NIH[P50-HG007735] ; NIH[R01GM109836] ; NIH[F32AR070565] ; California Institute for Regenerative Medicine tools[RT3-07796] ; National Natural Science Foundation of China[61671444] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[91730301] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13000000] ; EB Research Partnership
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:000458027300013
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/32522
专题	应用数学研究所
通讯作者	Oro, Anthony E.
作者单位	1.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA 2.Stanford Univ, Dept Dermatol, Sch Med, Stanford, CA 94305 USA 3.Stanford Univ, Dept Stat & Biomed Data Sci, Sch Med, Stanford, CA 94305 USA 4.Stanford Univ, Ctr Definit & Curat Med, Sch Med, Stanford, CA 94305 USA 5.Stanford Univ, Ctr Personal Dynam Regulome, Sch Med, Stanford, CA 94305 USA 6.Stanford Univ, Div Immunol & Rheumatol, Dept Med, Sch Med, Stanford, CA 94305 USA 7.Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Dept Pathol, Sch Med, Stanford, CA 94305 USA 8.Chinese Acad Sci, CEMS, NCMIS, MDIS,Acad Math & Syst Sci, Beijing 100080, Peoples R China 9.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Lingjie,Wang, Yong,Torkelson, Jessica L.,et al. TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment[J]. CELL STEM CELL,2019,24(2):271-+.
APA	Li, Lingjie.,Wang, Yong.,Torkelson, Jessica L..,Shankar, Gautam.,Pattison, Jillian M..,...&Oro, Anthony E..(2019).TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.CELL STEM CELL,24(2),271-+.
MLA	Li, Lingjie,et al."TFAP2C-and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment".CELL STEM CELL 24.2(2019):271-+.