KMS Of Academy of mathematics and systems sciences, CAS
| Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides | |
Du, Huiwen1,2,8; Hu, Xiaoyu3; Duan, Hongyang1,2,8; Yu, Lanlan1,2,8; Qu, Fuyang1,2,8; Huang, Qunxing1,2,8; Zheng, Wangshu1,2,8; Xie, Hanyi1,2,8; Peng, Jiaxi1,2,8; Tuo, Rui4 ; Yu, Dan4; Lin, Yuchen1,2,8; Li, Wenzhe1,2,8; Zheng, Yongfang1,2,8; Fang, Xiaocui1,2,8; Zou, Yimin1,2,8; Wang, Huayi1,2,8; Wang, Mengting1,2,8; Weiss, Paul S.5,6; Yang, Yanlian1,2,8; Wang, Chen1,2,7,8
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| 2019-01-23 | |
| Source Publication | ACS CENTRAL SCIENCE
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| ISSN | 2374-7943 |
| Volume | 5Issue:1Pages:97-108 |
| Abstract | We have determined the interaction strengths of the common naturally occurring amino acids using a complete binding affinity matrix of 20 x 20 pairs of homo-octapeptides consisting of the 20 common amino acids between stationary and mobile states. We used a bead-based fluorescence assay for these measurements. The results provide a basis for analyzing specificity, polymorphisms, and selectivity of inter-amino-acid interactions. Comparative analyses of the binding energies, i.e., the free energies of association (Delta G(A)), reveal contributions assignable to both main-chain-related and side-chain-related interactions originating from the chemical structures of these 20 common amino acids. Side-chain-side-chain and side-chain-main-chain interactions are found to be pronounced in an identified set of amino acid pairs that determine the basis of inter-amino-acid recognition. |
| DOI | 10.1021/acscentsci.8b00723 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[21673055] ; National Natural Science Foundation of China[21721002] ; National Natural Science Foundation of China[21773042] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SLH048] ; National Key Research and Development Program of China[2016YFF0203803] |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000456525100012 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/32181 |
| Collection | 系统科学研究所 |
| Corresponding Author | Weiss, Paul S.; Yang, Yanlian; Wang, Chen |
| Affiliation | 1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Math Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 5.Univ Calif Los Angeles, Dept Chem & Biochem, Calif NanoSyst Inst, Los Angeles, CA 90095 USA 6.Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA 7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Beijing 100101, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Du, Huiwen,Hu, Xiaoyu,Duan, Hongyang,et al. Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides[J]. ACS CENTRAL SCIENCE,2019,5(1):97-108. |
| APA | Du, Huiwen.,Hu, Xiaoyu.,Duan, Hongyang.,Yu, Lanlan.,Qu, Fuyang.,...&Wang, Chen.(2019).Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides.ACS CENTRAL SCIENCE,5(1),97-108. |
| MLA | Du, Huiwen,et al."Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides".ACS CENTRAL SCIENCE 5.1(2019):97-108. |
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