Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides

doi:10.1021/acscentsci.8b00723

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	Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides
	Du, Huiwen 1,2,8; Hu, Xiaoyu 3; Duan, Hongyang 1,2,8; Yu, Lanlan 1,2,8; Qu, Fuyang 1,2,8; Huang, Qunxing 1,2,8; Zheng, Wangshu 1,2,8; Xie, Hanyi 1,2,8; Peng, Jiaxi 1,2,8; Tuo, Rui4 ; Yu, Dan4 ; Lin, Yuchen 1,2,8; Li, Wenzhe 1,2,8; Zheng, Yongfang 1,2,8; Fang, Xiaocui 1,2,8; Zou, Yimin 1,2,8; Wang, Huayi 1,2,8; Wang, Mengting 1,2,8; Weiss, Paul S.5,6; Yang, Yanlian 1,2,8; Wang, Chen 1,2,7,8
	2019-01-23
发表期刊	ACS CENTRAL SCIENCE
ISSN	2374-7943
卷号	5 期号:1 页码:97-108
摘要	We have determined the interaction strengths of the common naturally occurring amino acids using a complete binding affinity matrix of 20 x 20 pairs of homo-octapeptides consisting of the 20 common amino acids between stationary and mobile states. We used a bead-based fluorescence assay for these measurements. The results provide a basis for analyzing specificity, polymorphisms, and selectivity of inter-amino-acid interactions. Comparative analyses of the binding energies, i.e., the free energies of association (Delta G(A)), reveal contributions assignable to both main-chain-related and side-chain-related interactions originating from the chemical structures of these 20 common amino acids. Side-chain-side-chain and side-chain-main-chain interactions are found to be pronounced in an identified set of amino acid pairs that determine the basis of inter-amino-acid recognition.
DOI	10.1021/acscentsci.8b00723
语种	英语
资助项目	National Natural Science Foundation of China[21673055] ; National Natural Science Foundation of China[21721002] ; National Natural Science Foundation of China[21773042] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-SLH048] ; National Key Research and Development Program of China[2016YFF0203803]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000456525100012
出版者	AMER CHEMICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/32181
专题	系统科学研究所
通讯作者	Weiss, Paul S.; Yang, Yanlian; Wang, Chen
作者单位	1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Standardizat & Measurement Nanotechnol, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Math Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 5.Univ Calif Los Angeles, Dept Chem & Biochem, Calif NanoSyst Inst, Los Angeles, CA 90095 USA 6.Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA 7.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Beijing 100101, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Du, Huiwen,Hu, Xiaoyu,Duan, Hongyang,et al. Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides[J]. ACS CENTRAL SCIENCE,2019,5(1):97-108.
APA	Du, Huiwen.,Hu, Xiaoyu.,Duan, Hongyang.,Yu, Lanlan.,Qu, Fuyang.,...&Wang, Chen.(2019).Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides.ACS CENTRAL SCIENCE,5(1),97-108.
MLA	Du, Huiwen,et al."Principles of Inter-Amino-Acid Recognition Revealed by Binding Energies between Homogeneous Oligopeptides".ACS CENTRAL SCIENCE 5.1(2019):97-108.