Substrate concentration effect on gene expression in genetic circuits with additional positive feedback

doi:10.1007/s11431-018-9301-0

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	Substrate concentration effect on gene expression in genetic circuits with additional positive feedback
	Wu, LuLu 1,2; Wang, Pei 3; Lu, JinHu1,2,4,5
	2018-08-01
发表期刊	SCIENCE CHINA-TECHNOLOGICAL SCIENCES
ISSN	1674-7321
卷号	61 期号:8 页码:1175-1183
摘要	In gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activation loops are ubiquitous regulatory motifs. This paper aims to investigate a two-component dual-positive feedback genetic circuit, which consists of a double negative feedback circuit and an additional positive feedback loop (APFL). We study effect of substrate concentration on gene expression in the single and the networked systems with APFLs, respectively. We find that substrate concentration can tune stochastic switch behavior in the signal system and then we explore relationship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we also discuss gene expression and stochastic switch behavior in the networked systems with APFLs. Based on analysis in the networked systems, we discover that genes express in some specific cells and do not express in the other cells when the expression achieves its steady state. These results can be used to well explain the character of regionalization in the expression of genes and the phenomenon of gene differentiation.
关键词	substrate concentration additional positive feedback loop stochastic switch behavior gene expression gene differentiation
DOI	10.1007/s11431-018-9301-0
语种	英语
资助项目	National Key Research and Development Program of China[2016YFB0800401] ; National Natural Science Foundation of China[61773153] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[61532020] ; National Natural Science Foundation of China[11472290] ; National Natural Science Foundation of China[61472027]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Multidisciplinary ; Materials Science, Multidisciplinary
WOS记录号	WOS:000440610100008
出版者	SCIENCE PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/31108
专题	系统科学研究所
通讯作者	Lu, JinHu
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 3.Henan Univ, Sch Math & Stat, Kaifeng 475004, Peoples R China 4.Beihang Univ, State Key Lab Software Dev Environm, Sch Automat Sci & Elect Engn, Beijing 100083, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data & Brain Machine, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Wu, LuLu,Wang, Pei,Lu, JinHu. Substrate concentration effect on gene expression in genetic circuits with additional positive feedback[J]. SCIENCE CHINA-TECHNOLOGICAL SCIENCES,2018,61(8):1175-1183.
APA	Wu, LuLu,Wang, Pei,&Lu, JinHu.(2018).Substrate concentration effect on gene expression in genetic circuits with additional positive feedback.SCIENCE CHINA-TECHNOLOGICAL SCIENCES,61(8),1175-1183.
MLA	Wu, LuLu,et al."Substrate concentration effect on gene expression in genetic circuits with additional positive feedback".SCIENCE CHINA-TECHNOLOGICAL SCIENCES 61.8(2018):1175-1183.