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Substrate concentration effect on gene expression in genetic circuits with additional positive feedback
Wu, LuLu1,2; Wang, Pei3; Lu, JinHu1,2,4,5
2018-08-01
Source PublicationSCIENCE CHINA-TECHNOLOGICAL SCIENCES
ISSN1674-7321
Volume61Issue:8Pages:1175-1183
AbstractIn gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation loops, auto-activation loops are ubiquitous regulatory motifs. This paper aims to investigate a two-component dual-positive feedback genetic circuit, which consists of a double negative feedback circuit and an additional positive feedback loop (APFL). We study effect of substrate concentration on gene expression in the single and the networked systems with APFLs, respectively. We find that substrate concentration can tune stochastic switch behavior in the signal system and then we explore relationship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we also discuss gene expression and stochastic switch behavior in the networked systems with APFLs. Based on analysis in the networked systems, we discover that genes express in some specific cells and do not express in the other cells when the expression achieves its steady state. These results can be used to well explain the character of regionalization in the expression of genes and the phenomenon of gene differentiation.
Keywordsubstrate concentration additional positive feedback loop stochastic switch behavior gene expression gene differentiation
DOI10.1007/s11431-018-9301-0
Language英语
Funding ProjectNational Key Research and Development Program of China[2016YFB0800401] ; National Natural Science Foundation of China[61773153] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[61532020] ; National Natural Science Foundation of China[11472290] ; National Natural Science Foundation of China[61472027]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Multidisciplinary ; Materials Science, Multidisciplinary
WOS IDWOS:000440610100008
PublisherSCIENCE PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/31108
Collection系统科学研究所
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
3.Henan Univ, Sch Math & Stat, Kaifeng 475004, Peoples R China
4.Beihang Univ, State Key Lab Software Dev Environm, Sch Automat Sci & Elect Engn, Beijing 100083, Peoples R China
5.Beihang Univ, Beijing Adv Innovat Ctr Big Data & Brain Machine, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wu, LuLu,Wang, Pei,Lu, JinHu. Substrate concentration effect on gene expression in genetic circuits with additional positive feedback[J]. SCIENCE CHINA-TECHNOLOGICAL SCIENCES,2018,61(8):1175-1183.
APA Wu, LuLu,Wang, Pei,&Lu, JinHu.(2018).Substrate concentration effect on gene expression in genetic circuits with additional positive feedback.SCIENCE CHINA-TECHNOLOGICAL SCIENCES,61(8),1175-1183.
MLA Wu, LuLu,et al."Substrate concentration effect on gene expression in genetic circuits with additional positive feedback".SCIENCE CHINA-TECHNOLOGICAL SCIENCES 61.8(2018):1175-1183.
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