Characteristics of distribution of Mycobacterium tuberculosis lineages in China

doi:10.1007/s11427-017-9243-0

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	Characteristics of distribution of Mycobacterium tuberculosis lineages in China
	Chen, Haixia 1,2,3; He, Li 4,5; Cai, Chao 6; Liu, Jingyi 1,2,3; Jia, Junnan 2,3,6,7; Ma, Liang 8; Huang, Hairong 2,3,6; Wang, Lixia 9; Ni, Xumin 10; Gao, Jimin 1; Li, Weimin 2,3,6,7
	2018-06-01
发表期刊	SCIENCE CHINA-LIFE SCIENCES
ISSN	1674-7305
卷号	61 期号:6 页码:651-659
摘要	The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.
关键词	Mycobacterium tuberculosis Lineage 2 Lineage 4 large sequence polymorphism fever
DOI	10.1007/s11427-017-9243-0
语种	英语
资助项目	National Natural Science Foundation of China[81273144] ; Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education[KZ201510025024] ; Fundamental Research Funds for the Central Universities[2017JBM071] ; China Postdoctoral Science Foundation[2017M620595]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000435974800005
出版者	SCIENCE PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/30608
专题	中国科学院数学与系统科学研究院
通讯作者	Ni, Xumin; Gao, Jimin; Li, Weimin
作者单位	1.Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China 2.Capital Med Univ, Beijing TB & Thorac Tumor Res Inst Beijing Chest, Natl TB Clin Lab China, Beijing 101149, Peoples R China 3.Capital Med Univ, Beijing Chest Hosp, Beijing 101149, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 6.Capital Med Univ, Beijing Chest Hosp, Beijing Key Lab Drug Resistance TB Res, Beijing 101149, Peoples R China 7.Capital Med Univ, Beijing Municipal Key Lab Clin Epidemiol, Sch Publ Hlth, Beijing 100069, Peoples R China 8.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China 9.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 102206, Peoples R China 10.Beijing Jiaotong Univ, Sch Sci, Dept Math, Beijing 100044, Peoples R China
推荐引用方式 GB/T 7714	Chen, Haixia,He, Li,Cai, Chao,et al. Characteristics of distribution of Mycobacterium tuberculosis lineages in China[J]. SCIENCE CHINA-LIFE SCIENCES,2018,61(6):651-659.
APA	Chen, Haixia.,He, Li.,Cai, Chao.,Liu, Jingyi.,Jia, Junnan.,...&Li, Weimin.(2018).Characteristics of distribution of Mycobacterium tuberculosis lineages in China.SCIENCE CHINA-LIFE SCIENCES,61(6),651-659.
MLA	Chen, Haixia,et al."Characteristics of distribution of Mycobacterium tuberculosis lineages in China".SCIENCE CHINA-LIFE SCIENCES 61.6(2018):651-659.