KMS Of Academy of mathematics and systems sciences, CAS
| Characteristics of distribution of Mycobacterium tuberculosis lineages in China | |
| Chen, Haixia1,2,3; He, Li4,5; Cai, Chao6; Liu, Jingyi1,2,3; Jia, Junnan2,3,6,7; Ma, Liang8; Huang, Hairong2,3,6; Wang, Lixia9; Ni, Xumin10; Gao, Jimin1; Li, Weimin2,3,6,7 | |
| 2018-06-01 | |
| Source Publication | SCIENCE CHINA-LIFE SCIENCES
 |
| ISSN | 1674-7305 |
| Volume | 61Issue:6Pages:651-659 |
| Abstract | The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. |
| Keyword | Mycobacterium tuberculosis Lineage 2 Lineage 4 large sequence polymorphism fever |
| DOI | 10.1007/s11427-017-9243-0 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81273144] ; Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education[KZ201510025024] ; Fundamental Research Funds for the Central Universities[2017JBM071] ; China Postdoctoral Science Foundation[2017M620595] |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics |
| WOS Subject | Biology |
| WOS ID | WOS:000435974800005 |
| Publisher | SCIENCE PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/30608 |
| Collection | 中国科学院数学与系统科学研究院 |
| Corresponding Author | Ni, Xumin; Gao, Jimin; Li, Weimin |
| Affiliation | 1.Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China 2.Capital Med Univ, Beijing TB & Thorac Tumor Res Inst Beijing Chest, Natl TB Clin Lab China, Beijing 101149, Peoples R China 3.Capital Med Univ, Beijing Chest Hosp, Beijing 101149, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 6.Capital Med Univ, Beijing Chest Hosp, Beijing Key Lab Drug Resistance TB Res, Beijing 101149, Peoples R China 7.Capital Med Univ, Beijing Municipal Key Lab Clin Epidemiol, Sch Publ Hlth, Beijing 100069, Peoples R China 8.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China 9.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 102206, Peoples R China 10.Beijing Jiaotong Univ, Sch Sci, Dept Math, Beijing 100044, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Haixia,He, Li,Cai, Chao,et al. Characteristics of distribution of Mycobacterium tuberculosis lineages in China[J]. SCIENCE CHINA-LIFE SCIENCES,2018,61(6):651-659. |
| APA | Chen, Haixia.,He, Li.,Cai, Chao.,Liu, Jingyi.,Jia, Junnan.,...&Li, Weimin.(2018).Characteristics of distribution of Mycobacterium tuberculosis lineages in China.SCIENCE CHINA-LIFE SCIENCES,61(6),651-659. |
| MLA | Chen, Haixia,et al."Characteristics of distribution of Mycobacterium tuberculosis lineages in China".SCIENCE CHINA-LIFE SCIENCES 61.6(2018):651-659. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment