The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms

doi:10.1109/TCBB.2016.2640963

CSpace > 应用数学研究所

	The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms
	Zhang, Junhua 1,2; Zhang, Shihua1,2
	2018-05-01
发表期刊	IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
ISSN	1545-5963
卷号	15 期号:3 页码:988-998
摘要	The pathogenesis of cancer in human is still poorly understood. With the rapid development of high-throughput sequencing technologies, huge volumes of cancer genomics data have been generated. Deciphering that data poses great opportunities and challenges to computational biologists. One of such key challenges is to distinguish driver mutations, genes as well as pathways from passenger ones. Mutual exclusivity of gene mutations (each patient has no more than one mutation in the gene set) has been observed in various cancer types and thus has been used as an important property of a driver gene set or pathway. In this article, we aim to review the recent development of computational models and algorithms for discovering driver pathways or modules in cancer with the focus on mutual exclusivity-based ones.
关键词	Bioinformatics cancer genomics driver gene driver pathway mutual exclusivity co-occurring mutation
DOI	10.1109/TCBB.2016.2640963
语种	英语
资助项目	National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11661141019] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Outstanding Young Scientist Program of CAS ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008] ; Key Laboratory of Random Complex Structures and Data Science, CAS[2008DP173182]
WOS研究方向	Biochemistry & Molecular Biology ; Computer Science ; Mathematics
WOS类目	Biochemical Research Methods ; Computer Science, Interdisciplinary Applications ; Mathematics, Interdisciplinary Applications ; Statistics & Probability
WOS记录号	WOS:000434295100028
出版者	IEEE COMPUTER SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/30412
专题	应用数学研究所
通讯作者	Zhang, Junhua
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Junhua,Zhang, Shihua. The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms[J]. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,2018,15(3):988-998.
APA	Zhang, Junhua,&Zhang, Shihua.(2018).The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms.IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS,15(3),988-998.
MLA	Zhang, Junhua,et al."The Discovery of Mutated Driver Pathways in Cancer: Models and Algorithms".IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS 15.3(2018):988-998.