Large-scale determination and characterization of cell type-specific regulatory elements in the human genome

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	Large-scale determination and characterization of cell type-specific regulatory elements in the human genome
	Wang Can; Zhang Shihua
	2017
发表期刊	Journal of Molecular Cell Biology
ISSN	1674-2788
卷号	9 期号:6 页码:463
摘要	Histone modifications have been widely elucidated to play vital roles in gene regulation and cell identity. The Roadmap Epigenomics Consortium generated a reference catalog of several key histone modifications across >100s of human cell types and tissues. Decoding these epigenomes into functional regulatory elements is a challenging task in computational biology. To this end, we adopted a differential chromatin modification analysis framework to comprehensively determine and characterize cell type-specific regulatory elements (CSREs) and their histone modification codes in the human epigenomes of five histone modifications across 127 tissues or cell types. The CSREs show significant relevance with cell type-specific biological functions and diseases and cell identity. Clustering of CSREs with their specificity signals reveals distinct histone codes, demonstrating the diversity of functional roles of CSREs within the same cell or tissue. Last but not least, dynamics of CSREs from close cell types or tissues can give a detailed view of developmental processes such as normal tissue development and cancer occurrence.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/29662
专题	应用数学研究所
作者单位	中国科学院数学与系统科学研究院
推荐引用方式 GB/T 7714	Wang Can,Zhang Shihua. Large-scale determination and characterization of cell type-specific regulatory elements in the human genome[J]. Journal of Molecular Cell Biology,2017,9(6):463.
APA	Wang Can,&Zhang Shihua.(2017).Large-scale determination and characterization of cell type-specific regulatory elements in the human genome.Journal of Molecular Cell Biology,9(6),463.
MLA	Wang Can,et al."Large-scale determination and characterization of cell type-specific regulatory elements in the human genome".Journal of Molecular Cell Biology 9.6(2017):463.