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Large-scale determination and characterization of cell type-specific regulatory elements in the human genome
Wang, Can1,2; Zhang, Shihua1,2
2017-12-01
Source PublicationJOURNAL OF MOLECULAR CELL BIOLOGY
ISSN1674-2788
Volume9Issue:6Pages:463-476
AbstractHistone modifications have been widely elucidated to play vital roles in gene regulation and cell identity. The Roadmap Epigenomics Consortium generated a reference catalog of several key histone modifications across >100s of human cell types and tissues. Decoding these epigenomes into functional regulatory elements is a challenging task in computational biology. To this end, we adopted a differential chromatin modification analysis framework to comprehensively determine and characterize cell type-specific regulatory elements (CSREs) and their histone modification codes in the human epigenomes of five histone modifications across 127 tissues or cell types. The CSREs show significant relevance with cell type-specific biological functions and diseases and cell identity. Clustering of CSREs with their specificity signals reveals distinct histone codes, demonstrating the diversity of functional roles of CSREs within the same cell or tissue. Last but not least, dynamics of CSREs from close cell types or tissues can give a detailed view of developmental processes such as normal tissue development and cancer occurrence.
Keywordepigenomics histone modification cell type-specific regulatory elements bioinformatics
DOI10.1093/jmcb/mjx058
Language英语
Funding ProjectNational Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11661141019] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61379092] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[11661141019] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008]
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000425284600004
PublisherOXFORD UNIV PRESS
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Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/29662
Collection应用数学研究所
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, RCSDS, NCMIS,CEMS, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Can,Zhang, Shihua. Large-scale determination and characterization of cell type-specific regulatory elements in the human genome[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2017,9(6):463-476.
APA Wang, Can,&Zhang, Shihua.(2017).Large-scale determination and characterization of cell type-specific regulatory elements in the human genome.JOURNAL OF MOLECULAR CELL BIOLOGY,9(6),463-476.
MLA Wang, Can,et al."Large-scale determination and characterization of cell type-specific regulatory elements in the human genome".JOURNAL OF MOLECULAR CELL BIOLOGY 9.6(2017):463-476.
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