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Large-scale determination and characterization of cell type-specific regulatory elements in the human genome
Wang Can; Zhang Shihua
2017
Source PublicationJournal of Molecular Cell Biology
ISSN1674-2788
Volume9Issue:6Pages:463
AbstractHistone modifications have been widely elucidated to play vital roles in gene regulation and cell identity. The Roadmap Epigenomics Consortium generated a reference catalog of several key histone modifications across >100s of human cell types and tissues. Decoding these epigenomes into functional regulatory elements is a challenging task in computational biology. To this end, we adopted a differential chromatin modification analysis framework to comprehensively determine and characterize cell type-specific regulatory elements (CSREs) and their histone modification codes in the human epigenomes of five histone modifications across 127 tissues or cell types. The CSREs show significant relevance with cell type-specific biological functions and diseases and cell identity. Clustering of CSREs with their specificity signals reveals distinct histone codes, demonstrating the diversity of functional roles of CSREs within the same cell or tissue. Last but not least, dynamics of CSREs from close cell types or tissues can give a detailed view of developmental processes such as normal tissue development and cancer occurrence.
Language英语
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/29662
Collection应用数学研究所
Affiliation中国科学院数学与系统科学研究院
Recommended Citation
GB/T 7714
Wang Can,Zhang Shihua. Large-scale determination and characterization of cell type-specific regulatory elements in the human genome[J]. Journal of Molecular Cell Biology,2017,9(6):463.
APA Wang Can,&Zhang Shihua.(2017).Large-scale determination and characterization of cell type-specific regulatory elements in the human genome.Journal of Molecular Cell Biology,9(6),463.
MLA Wang Can,et al."Large-scale determination and characterization of cell type-specific regulatory elements in the human genome".Journal of Molecular Cell Biology 9.6(2017):463.
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