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NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations
Chen, Xing1; Sun, Ya-Zhou2; Zhang, De-Hong1; Li, Jian-Qiang2; Yan, Gui-Ying3; An, Ji-Yong4; You, Zhu-Hong5
2017-07-21
Source PublicationDATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
ISSN1758-0463
Pages6
AbstractIn recent years, more and more non-coding RNAs (ncRNAs) have been identified and increasing evidences have shown that ncRNAs may affect gene expression and disease progression, making them a new class of targets for drug discovery. It thus becomes important to understand the relationship between ncRNAs and drug targets. For this purpose, an ncRNAs and drug targets association database would be extremely beneficial. Here, we developed ncRNA Drug Targets Database (NRDTD) that collected 165 entries of clinically or experimentally supported ncRNAs as drug targets, including 97 ncRNAs and 96 drugs. Moreover, we annotated ncRNA-drug target associations with drug information from KEGG, PubChem, DrugBank, CTD or Wikipedia, GenBank sequence links, OMIM disease ID, pathway and function annotation for ncRNAs, detailed description of associations between ncRNAs and diseases from HMDD or LncRNADisease and the publication PubMed ID. Additionally, we provided users a link to submit novel diseasenc-RNA-drug associations and corresponding supporting evidences into the database. We hope NRDTD will be a useful resource for investigating the roles of ncRNAs in drug target identification, drug discovery and disease treatment.
DOI10.1093/database/bax057
Language英语
Funding ProjectNational Natural Science Foundation of China[11631014] ; National Natural Science Foundation of China[11371355] ; National Natural Science Foundation of China[61572506] ; National Natural Science Foundation of China[61202159] ; National Natural Science Foundation of China[61572330] ; Natural Science foundation of Guangdong Province[2014A030313554] ; Science and Technology Planning Project of Guangdong Province[2014B010118005]
WOS Research AreaMathematical & Computational Biology
WOS SubjectMathematical & Computational Biology
WOS IDWOS:000407488700001
PublisherOXFORD UNIV PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/26554
Collection应用数学研究所
Corresponding AuthorChen, Xing; Li, Jian-Qiang
Affiliation1.China Univ Min & Technol, Sch Informat & Control Engn, Xuzhou 221116, Peoples R China
2.Shenzhen Univ, Coll Comp Sci & Software Engn, Shenzhen 518060, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
4.China Univ Min & Technol, Sch Comp Sci & Technol, Xuzhou 21116, Peoples R China
5.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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Chen, Xing,Sun, Ya-Zhou,Zhang, De-Hong,et al. NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2017:6.
APA Chen, Xing.,Sun, Ya-Zhou.,Zhang, De-Hong.,Li, Jian-Qiang.,Yan, Gui-Ying.,...&You, Zhu-Hong.(2017).NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,6.
MLA Chen, Xing,et al."NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2017):6.
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