KMS Of Academy of mathematics and systems sciences, CAS
NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations | |
Chen, Xing1; Sun, Ya-Zhou2; Zhang, De-Hong1; Li, Jian-Qiang2; Yan, Gui-Ying3; An, Ji-Yong4; You, Zhu-Hong5 | |
2017-07-21 | |
发表期刊 | DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION |
ISSN | 1758-0463 |
页码 | 6 |
摘要 | In recent years, more and more non-coding RNAs (ncRNAs) have been identified and increasing evidences have shown that ncRNAs may affect gene expression and disease progression, making them a new class of targets for drug discovery. It thus becomes important to understand the relationship between ncRNAs and drug targets. For this purpose, an ncRNAs and drug targets association database would be extremely beneficial. Here, we developed ncRNA Drug Targets Database (NRDTD) that collected 165 entries of clinically or experimentally supported ncRNAs as drug targets, including 97 ncRNAs and 96 drugs. Moreover, we annotated ncRNA-drug target associations with drug information from KEGG, PubChem, DrugBank, CTD or Wikipedia, GenBank sequence links, OMIM disease ID, pathway and function annotation for ncRNAs, detailed description of associations between ncRNAs and diseases from HMDD or LncRNADisease and the publication PubMed ID. Additionally, we provided users a link to submit novel diseasenc-RNA-drug associations and corresponding supporting evidences into the database. We hope NRDTD will be a useful resource for investigating the roles of ncRNAs in drug target identification, drug discovery and disease treatment. |
DOI | 10.1093/database/bax057 |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[11631014] ; National Natural Science Foundation of China[11371355] ; National Natural Science Foundation of China[61572506] ; National Natural Science Foundation of China[61202159] ; National Natural Science Foundation of China[61572330] ; Natural Science foundation of Guangdong Province[2014A030313554] ; Science and Technology Planning Project of Guangdong Province[2014B010118005] |
WOS研究方向 | Mathematical & Computational Biology |
WOS类目 | Mathematical & Computational Biology |
WOS记录号 | WOS:000407488700001 |
出版者 | OXFORD UNIV PRESS |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.amss.ac.cn/handle/2S8OKBNM/26554 |
专题 | 应用数学研究所 |
通讯作者 | Chen, Xing; Li, Jian-Qiang |
作者单位 | 1.China Univ Min & Technol, Sch Informat & Control Engn, Xuzhou 221116, Peoples R China 2.Shenzhen Univ, Coll Comp Sci & Software Engn, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 4.China Univ Min & Technol, Sch Comp Sci & Technol, Xuzhou 21116, Peoples R China 5.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Xing,Sun, Ya-Zhou,Zhang, De-Hong,et al. NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2017:6. |
APA | Chen, Xing.,Sun, Ya-Zhou.,Zhang, De-Hong.,Li, Jian-Qiang.,Yan, Gui-Ying.,...&You, Zhu-Hong.(2017).NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,6. |
MLA | Chen, Xing,et al."NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2017):6. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论