Mycobacterium tuberculosis Lineage Distribution in Xinjiang and Gansu Provinces, China

doi:10.1038/s41598-017-00720-9

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	Mycobacterium tuberculosis Lineage Distribution in Xinjiang and Gansu Provinces, China
	Chen, Haixia 1,2; He, Li 3; Huang, Hairong 2,4; Shi, Chengmin 5; Ni, Xumin 6; Dai, Guangming 2,4; Ma, Liang 5; Li, Weimin 2,4,7
	2017-04-21
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7 页码:7
摘要	Mycobacterium tuberculosis (M. tuberculosis) genotyping has dramatically improved the understanding of the epidemiology of tuberculosis (TB). In this study, 187 M. tuberculosis isolates from Xinjiang Uygur Autonomous Region (Xinjiang) and Gansu province in China were genotyped using large sequence polymorphisms (LSPs) and variable number tandem repeats (VNTR). Ten isolates, which represent major nodes of VNTR-based minimum spanning tree, were selected and subsequently subjected to multi-locus sequence analyses (MLSA) that include 82 genes. Based on a robust lineage assignment, we tested the association between lineages and clinical characteristics by logistic regression. There are three major lineages of M. tuberculosis prevalent in Xinjiang, viz. the East Asian Lineage 2 (42.1%; 56/133), the Euro-American Lineage 4 (33.1%; 44/133), and the Indian and East African Lineage 3 (24.8%; 33/133); two lineages prevalent in Gansu province, which are the Lineage 2 (87%; 47/54) and the Lineage 4 (13%; 7/54). The topological structures of the MLSA-based phylogeny support the LSP-based identification of M. tuberculosis lineages. The statistical results suggest an association between the Lineage 2 and the hemoptysis/bloody sputum symptom, fever in Uygur patients. The pathogenicity of the Lineage 2 remains to be further investigated.
DOI	10.1038/s41598-017-00720-9
语种	英语
资助项目	National Natural Science Foundation of China[81273144] ; Scientific Research Key Program of Beijing Municipal Commission of Education[KZ201510025024] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201304] ; National Centre for Mathematics, Interdisciplinary Sciences (NCMIS) ; Beijing Natural Science Foundation Program
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000399972900067
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/26093
专题	中国科学院数学与系统科学研究院
通讯作者	Ma, Liang; Li, Weimin
作者单位	1.Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China 2.Capital Med Univ, Beijing Chest Hosp, Natl TB Clin Lab China, Beijing TB & Thorac Tumor Res Inst, Beijing 101149, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 4.Capital Med Univ, Beijing Chest Hosp, Beijing Key Lab Drug Resistance TB Res, Beijing 101149, Peoples R China 5.Chinese Acad Sci, Beijing Inst Gen, Beijing 100101, Peoples R China 6.Beijing Jiaotong Univ, Sch Sci, Dept Math, Beijing 100044, Peoples R China 7.Capital Med Univ, Sch Publ Hlth, Beijing Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China
推荐引用方式 GB/T 7714	Chen, Haixia,He, Li,Huang, Hairong,et al. Mycobacterium tuberculosis Lineage Distribution in Xinjiang and Gansu Provinces, China[J]. SCIENTIFIC REPORTS,2017,7:7.
APA	Chen, Haixia.,He, Li.,Huang, Hairong.,Shi, Chengmin.,Ni, Xumin.,...&Li, Weimin.(2017).Mycobacterium tuberculosis Lineage Distribution in Xinjiang and Gansu Provinces, China.SCIENTIFIC REPORTS,7,7.
MLA	Chen, Haixia,et al."Mycobacterium tuberculosis Lineage Distribution in Xinjiang and Gansu Provinces, China".SCIENTIFIC REPORTS 7(2017):7.