A Novel Dual Eigen-Analysis of Mouse Multi-Tissues' Expression Profiles Unveils New Perspectives into Type 2 Diabetes

doi:10.1038/s41598-017-05405-x

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	A Novel Dual Eigen-Analysis of Mouse Multi-Tissues' Expression Profiles Unveils New Perspectives into Type 2 Diabetes
	Li, Lei M.1,2 ; Liu, Xiuxiu 3,4; Wang, Lin 1,5; Wang, Yong 1; Liu, Xiuqin 1,6; Tian, Xue 1; Gong, Fuzhou1,2 ; Shen, Li 3; Peng, Xiao-ding 7
	2017-07-11
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7 页码:12
摘要	Type 2 diabetes (T2D) is a complex and polygenic disease yet in need of a complete picture of its development mechanisms. To better understand the mechanisms, we examined gene expression profiles of multi-tissues from outbred mice fed with a high-fat diet (HFD) or regular chow at weeks 1, 9, and 18. To analyze such complex data, we proposed a novel dual eigen-analysis, in which the sample-and gene-eigenvectors correspond respectively to the macro-and micro-biology information. The dual eigen-analysis identified the HFD eigenvectors as well as the endogenous eigenvectors for each tissue. The results imply that HFD influences the hepatic function or the pancreatic development as an exogenous factor, while in adipose HFD's impact roughly coincides with the endogenous eigenvector driven by aging. The enrichment analysis of the eigenvectors revealed diverse HFD impact on the three tissues over time. The diversity includes: inflammation, degradation of branched chain amino acids (BCAA), and regulation of peroxisome proliferator activated receptor gamma (PPAR gamma). We reported that in the pancreas remarkable up-regulation of angiogenesis as downstream of the HIF signaling pathway precedes hyperinsulinemia. The dual eigen-analysis and discoveries provide new evaluations/guidance in T2D prevention and therapy, and will also promote new thinking in biology and medicine.
DOI	10.1038/s41598-017-05405-x
语种	英语
资助项目	National Center for Mathematics and Interdisciplinary Sciences of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13040600] ; National Natural Science Foundation of China[91130008] ; National Natural Science Foundation of China[91530105] ; Key Laboratory of Systems and Control of the CAS ; Scientific Research Level Improvement Quota Project of Capital University of Economics and Business ; National High-tech R& D Program of China (863 Program)[2012AA020505]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000405172600011
出版者	NATURE PUBLISHING GROUP
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/25942
专题	应用数学研究所系统科学研究所
通讯作者	Li, Lei M.; Peng, Xiao-ding
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Dept Cell Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China 4.Shandong Univ, Dept Otorhinolaryngol Head & Neck Surg, Shandong Prov Key Lab Otol, Shandong Prov Hosp, Jinan 250021, Peoples R China 5.Capital Univ Econ & Business, Sch Stat, Beijing, Peoples R China 6.Univ Sci & Technol Beijing, Sch Math & Phys, Beijing, Peoples R China 7.Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60607 USA
推荐引用方式 GB/T 7714	Li, Lei M.,Liu, Xiuxiu,Wang, Lin,et al. A Novel Dual Eigen-Analysis of Mouse Multi-Tissues' Expression Profiles Unveils New Perspectives into Type 2 Diabetes[J]. SCIENTIFIC REPORTS,2017,7:12.
APA	Li, Lei M..,Liu, Xiuxiu.,Wang, Lin.,Wang, Yong.,Liu, Xiuqin.,...&Peng, Xiao-ding.(2017).A Novel Dual Eigen-Analysis of Mouse Multi-Tissues' Expression Profiles Unveils New Perspectives into Type 2 Diabetes.SCIENTIFIC REPORTS,7,12.
MLA	Li, Lei M.,et al."A Novel Dual Eigen-Analysis of Mouse Multi-Tissues' Expression Profiles Unveils New Perspectives into Type 2 Diabetes".SCIENTIFIC REPORTS 7(2017):12.