Joint modeling of recurrent and terminal events using additive models

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	Joint modeling of recurrent and terminal events using additive models
	Qu, Lianqiang 1; Sun, Liuquan1 ; Liu, Lei 2
	2017
发表期刊	STATISTICS AND ITS INTERFACE
ISSN	1938-7989
卷号	10 期号:4 页码:699-710
摘要	In this article, we propose a joint modeling approach for the analysis of recurrent event data with a terminal event. We specify an additive rates model with a multiplicative frailty for the conditional recurrent event rate, and an additive hazards frailty model for the terminal event. A shared frailty is used to account for the association between recurrent and terminal events. An estimating equation approach is developed for the marginal and association parameters in the joint model, and the asymptotic properties of the proposed estimators are established. The finite sample performance of the proposed estimators is examined through simulation studies, and an application to a medical cost study of chronic heart failure patients is illustrated.
关键词	Additive models Estimating equations Frailty Partial marginal models Recurrent events Terminal event
语种	英语
资助项目	National Natural Science Foundation of China[11231010] ; National Natural Science Foundation of China[11171330] ; Key Laboratory of RCSDS ; CAS[2008DP173182] ; BCMIIS ; Agency of Healthcare Research and Quality of USA[R01 HS 020263]
WOS研究方向	Mathematical & Computational Biology ; Mathematics
WOS类目	Mathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS记录号	WOS:000402401300012
出版者	INT PRESS BOSTON, INC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/25693
专题	应用数学研究所
通讯作者	Sun, Liuquan
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China 2.Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA
推荐引用方式 GB/T 7714	Qu, Lianqiang,Sun, Liuquan,Liu, Lei. Joint modeling of recurrent and terminal events using additive models[J]. STATISTICS AND ITS INTERFACE,2017,10(4):699-710.
APA	Qu, Lianqiang,Sun, Liuquan,&Liu, Lei.(2017).Joint modeling of recurrent and terminal events using additive models.STATISTICS AND ITS INTERFACE,10(4),699-710.
MLA	Qu, Lianqiang,et al."Joint modeling of recurrent and terminal events using additive models".STATISTICS AND ITS INTERFACE 10.4(2017):699-710.