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Joint modeling of recurrent and terminal events using additive models
Qu, Lianqiang1; Sun, Liuquan1; Liu, Lei2
2017
Source PublicationSTATISTICS AND ITS INTERFACE
ISSN1938-7989
Volume10Issue:4Pages:699-710
AbstractIn this article, we propose a joint modeling approach for the analysis of recurrent event data with a terminal event. We specify an additive rates model with a multiplicative frailty for the conditional recurrent event rate, and an additive hazards frailty model for the terminal event. A shared frailty is used to account for the association between recurrent and terminal events. An estimating equation approach is developed for the marginal and association parameters in the joint model, and the asymptotic properties of the proposed estimators are established. The finite sample performance of the proposed estimators is examined through simulation studies, and an application to a medical cost study of chronic heart failure patients is illustrated.
KeywordAdditive models Estimating equations Frailty Partial marginal models Recurrent events Terminal event
Language英语
Funding ProjectNational Natural Science Foundation of China[11231010] ; National Natural Science Foundation of China[11171330] ; Key Laboratory of RCSDS ; CAS[2008DP173182] ; BCMIIS ; Agency of Healthcare Research and Quality of USA[R01 HS 020263]
WOS Research AreaMathematical & Computational Biology ; Mathematics
WOS SubjectMathematical & Computational Biology ; Mathematics, Interdisciplinary Applications
WOS IDWOS:000402401300012
PublisherINT PRESS BOSTON, INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.amss.ac.cn/handle/2S8OKBNM/25693
Collection应用数学研究所
Affiliation1.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100190, Peoples R China
2.Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA
Recommended Citation
GB/T 7714
Qu, Lianqiang,Sun, Liuquan,Liu, Lei. Joint modeling of recurrent and terminal events using additive models[J]. STATISTICS AND ITS INTERFACE,2017,10(4):699-710.
APA Qu, Lianqiang,Sun, Liuquan,&Liu, Lei.(2017).Joint modeling of recurrent and terminal events using additive models.STATISTICS AND ITS INTERFACE,10(4),699-710.
MLA Qu, Lianqiang,et al."Joint modeling of recurrent and terminal events using additive models".STATISTICS AND ITS INTERFACE 10.4(2017):699-710.
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