KMS Of Academy of mathematics and systems sciences, CAS
| A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information | |
Hu Xiaonan1,2; Duan Xiaogang3; Pan Dongdong4; Zhang Sanguo1,2; Li Qizhai5
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| 2017-02-01 | |
| Source Publication | JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY
 |
| ISSN | 1009-6124 |
| Volume | 30Issue:1Pages:101-110 |
| Abstract | The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test. |
| Keyword | Genetic model hardy-weinberg equilibrium power robust trend test |
| DOI | 10.1007/s11424-017-6187-4 |
| Language | 英语 |
| Funding Project | Special National Key Research and Development Plan[2016YFD0400206] ; Breakthrough Project of Strategic Priority Program of Chinese Academy of Sciences[XDB13040600] ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Science Foundation of China[11371353] ; National Science Foundation of China[11661080] ; National Science Foundation of China[61134013] ; Special Fund of the University of Chinese Academy of Sciences for Scientific Research Cooperation |
| WOS Research Area | Mathematics |
| WOS Subject | Mathematics, Interdisciplinary Applications |
| WOS ID | WOS:000397236700008 |
| Publisher | SPRINGER HEIDELBERG |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.amss.ac.cn/handle/2S8OKBNM/25114 |
| Collection | 系统科学研究所 |
| Corresponding Author | Pan Dongdong |
| Affiliation | 1.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Big Data Min & Knowledge Management, Beijing 100190, Peoples R China 3.Beijing Normal Univ, Sch Stat, Beijing 100875, Peoples R China 4.Yunnan Univ, Dept Stat, Kunming 650091, Peoples R China 5.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Hu Xiaonan,Duan Xiaogang,Pan Dongdong,et al. A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information[J]. JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY,2017,30(1):101-110. |
| APA | Hu Xiaonan,Duan Xiaogang,Pan Dongdong,Zhang Sanguo,&Li Qizhai.(2017).A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information.JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY,30(1),101-110. |
| MLA | Hu Xiaonan,et al."A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information".JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY 30.1(2017):101-110. |
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