A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information

doi:10.1007/s11424-017-6187-4

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	A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information
	Hu Xiaonan 1,2; Duan Xiaogang 3; Pan Dongdong 4; Zhang Sanguo 1,2; Li Qizhai5
	2017-02-01
发表期刊	JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY
ISSN	1009-6124
卷号	30 期号:1 页码:101-110
摘要	The genetic models are greatly important in the analysis of genetic epidemiologic studies and many of the studies are conducted using the trend test under the additive model. However, for many complex diseases and traits, the underlying genetic model for a genetic locus is usually uncertain. So a robust test free of genetic model is appropriate. In this paper, the authors propose a model-embedded trend test by incorporating Hardy-Weinberg equilibrium information and obtain the explicit formula to calculate its statistical significance. Extensive simulation studies show the proposed test is more robust than the existing procedures. Finally, a real application is further analyzed to show the performance of the proposed test.
关键词	Genetic model hardy-weinberg equilibrium power robust trend test
DOI	10.1007/s11424-017-6187-4
语种	英语
资助项目	Special National Key Research and Development Plan[2016YFD0400206] ; Breakthrough Project of Strategic Priority Program of Chinese Academy of Sciences[XDB13040600] ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Science Foundation of China[11371353] ; National Science Foundation of China[11661080] ; National Science Foundation of China[61134013] ; Special Fund of the University of Chinese Academy of Sciences for Scientific Research Cooperation
WOS研究方向	Mathematics
WOS类目	Mathematics, Interdisciplinary Applications
WOS记录号	WOS:000397236700008
出版者	SPRINGER HEIDELBERG
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/25114
专题	系统科学研究所
通讯作者	Pan Dongdong
作者单位	1.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Big Data Min & Knowledge Management, Beijing 100190, Peoples R China 3.Beijing Normal Univ, Sch Stat, Beijing 100875, Peoples R China 4.Yunnan Univ, Dept Stat, Kunming 650091, Peoples R China 5.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Hu Xiaonan,Duan Xiaogang,Pan Dongdong,et al. A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information[J]. JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY,2017,30(1):101-110.
APA	Hu Xiaonan,Duan Xiaogang,Pan Dongdong,Zhang Sanguo,&Li Qizhai.(2017).A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information.JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY,30(1),101-110.
MLA	Hu Xiaonan,et al."A Model-Embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information".JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY 30.1(2017):101-110.