IRWRLDA: improved random walk with restart for lncRNA-disease association prediction

doi:10.18632/oncotarget.11141

CSpace > 应用数学研究所

	IRWRLDA: improved random walk with restart for lncRNA-disease association prediction
	Chen, Xing 1; You, Zhu-Hong 2; Yan, Gui-Ying3,4 ; Gong, Dun-Wei 1
	2016-09-06
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	7 期号:36 页码:57919-57931
摘要	In recent years, accumulating evidences have shown that the dysregulations of lncRNAs are associated with a wide range of human diseases. It is necessary and feasible to analyze known lncRNA-disease associations, predict potential lncRNA-disease associations, and provide the most possible lncRNA-disease pairs for experimental validation. Considering the limitations of traditional Random Walk with Restart (RWR), the model of Improved Random Walk with Restart for LncRNA-Disease Association prediction (IRWRLDA) was developed to predict novel lncRNA-disease associations by integrating known lncRNA-disease associations, disease semantic similarity, and various lncRNA similarity measures. The novelty of IRWRLDA lies in the incorporation of lncRNA expression similarity and disease semantic similarity to set the initial probability vector of the RWR. Therefore, IRWRLDA could be applied to diseases without any known related lncRNAs. IRWRLDA significantly improved previous classical models with reliable AUCs of 0.7242 and 0.7872 in two known lncRNA-disease association datasets downloaded from the lncRNA-Disease database, respectively. Further case studies of colon cancer and leukemia were implemented for IRWRLDA and 60% of lncRNAs in the top 10 prediction lists have been confirmed by recent experimental reports.
关键词	lncRNAs disease cancer random walk with restart
DOI	10.18632/oncotarget.11141
语种	英语
资助项目	National Natural Science Foundation of China[11301517] ; National Natural Science Foundation of China[61572506] ; National Natural Science Foundation of China[11371355]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000387153200036
出版者	IMPACT JOURNALS LLC
引用统计
文献类型	期刊论文
条目标识符	http://ir.amss.ac.cn/handle/2S8OKBNM/24066
专题	应用数学研究所
通讯作者	Chen, Xing; You, Zhu-Hong
作者单位	1.China Univ Min & Technol, Sch Informat & Elect Engn, Xuzhou 221116, Peoples R China 2.China Univ Min & Technol, Sch Comp Sci & Technol, Xuzhou 221116, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xing,You, Zhu-Hong,Yan, Gui-Ying,et al. IRWRLDA: improved random walk with restart for lncRNA-disease association prediction[J]. ONCOTARGET,2016,7(36):57919-57931.
APA	Chen, Xing,You, Zhu-Hong,Yan, Gui-Ying,&Gong, Dun-Wei.(2016).IRWRLDA: improved random walk with restart for lncRNA-disease association prediction.ONCOTARGET,7(36),57919-57931.
MLA	Chen, Xing,et al."IRWRLDA: improved random walk with restart for lncRNA-disease association prediction".ONCOTARGET 7.36(2016):57919-57931.